Woolf L I, Groves A C, Duff J H
Surgery. 1979 Feb;85(2):212-8.
In 10 fasting dogs receiving 10(9) viable E. coli bacteria per kilogram intravenously, mean systolic blood pressure decreased from 120.6 +/- 15.1 to 82.2 +/- 12.8 mm Hg. The association of hypoglycemia and increased arterial alanine and glycine with elevated plasma glucagon implied impaired gluconeogenesis. A rapid elevation of blood urea concentration, indicating increased ureagenesis, a fall of blood glucose, and an increase of net urea synthesis relative to that of glucose suggested that an increased proportion of the carbon residues derived from glucogenic amino acids is catabolized via pathways other than gluconeogenesis. In the bacteremic dogs the absolute net release from the leg of valine, isoleucine, and leucine and their net release relative to the net rate of proteolysis were decreased, suggesting increased oxidation of these amino acids in skeletal muscle. An increased net release of alanine relative to the net rate of protein catabolism in muscle was in agreement with this contention.
在10只禁食的犬中，每千克静脉注射10⁹个活的大肠杆菌，平均收缩压从120.6±15.1毫米汞柱降至82.2±12.8毫米汞柱。低血糖、动脉丙氨酸和甘氨酸增加以及血浆胰高血糖素升高之间的关联表明糖异生受损。血尿素浓度迅速升高，表明尿素生成增加，血糖下降，相对于葡萄糖的净尿素合成增加，这表明生糖氨基酸衍生的碳残基通过糖异生以外的途径分解代谢的比例增加。在菌血症犬中，缬氨酸、异亮氨酸和亮氨酸从腿部的绝对净释放量及其相对于蛋白水解净速率的净释放量降低，表明这些氨基酸在骨骼肌中的氧化增加。肌肉中丙氨酸相对于蛋白质分解代谢净速率的净释放量增加与这一观点一致。
