基质金属蛋白酶 12 在口腔环境中的新作用。
The Emerging Role of MMP12 in the Oral Environment.
机构信息
Novel Bacteria and Drug Discovery Research Group (NBDD), Microbiome and Bioresource Research Strength (MBRS), Jeffrey Cheah School of Medicine and Health Sciences, Monash University Malaysia, Bandar Sunway 47500, Selangor Darul Ehsan, Malaysia.
Department of Orthodontics, Affiliated Stomatology Hospital of Guangzhou Medical University, Guangzhou 510180, China.
出版信息
Int J Mol Sci. 2023 Feb 28;24(5):4648. doi: 10.3390/ijms24054648.
Matrix metalloproteinase-12 (MMP12), or macrophage metalloelastase, plays important roles in extracellular matrix (ECM) component degradation. Recent reports show MMP12 has been implicated in the pathogenesis of periodontal diseases. To date, this review represents the latest comprehensive overview of MMP12 in various oral diseases, such as periodontitis, temporomandibular joint dysfunction (TMD), orthodontic tooth movement (OTM), and oral squamous cell carcinoma (OSCC). Furthermore, the current knowledge regarding the distribution of MMP12 in different tissues is also illustrated in this review. Studies have implicated the association of MMP12 expression with the pathogenesis of several representative oral diseases, including periodontitis, TMD, OSCC, OTM, and bone remodelling. Although there may be a potential role of MMP12 in oral diseases, the exact pathophysiological role of MMP12 remains to be elucidated. Understanding the cellular and molecular biology of MMP12 is essential, as MMP12 could be a potential target for developing therapeutic strategies targeting inflammatory and immunologically related oral diseases.
基质金属蛋白酶 12（MMP12），又称巨噬细胞弹性蛋白酶，在细胞外基质（ECM）成分降解中发挥重要作用。最近的报告表明，MMP12 与牙周病等牙周病的发病机制有关。迄今为止，这篇综述代表了 MMP12 在各种口腔疾病（如牙周炎、颞下颌关节功能障碍（TMD）、正畸牙齿移动（OTM）和口腔鳞状细胞癌（OSCC））中的最新全面概述。此外，本综述还阐述了目前关于 MMP12 在不同组织中分布的知识。研究表明，MMP12 的表达与几种代表性口腔疾病（包括牙周炎、TMD、OSCC、OTM 和骨重塑）的发病机制有关。尽管 MMP12 可能在口腔疾病中具有潜在作用，但 MMP12 的确切病理生理作用仍有待阐明。了解 MMP12 的细胞和分子生物学是必要的，因为 MMP12 可能成为开发针对炎症和免疫相关口腔疾病的治疗策略的潜在靶点。
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