Anesthesiology and Intensive Care Department, Marie Lannelongue Surgical Hospital, 133 Avenue de la Résistance, 92350 Le Plessis Robinson, France.
Intensive Care Unit, Cayenne General Hospital, Av des Flamboyants, 97306 Cayenne, France.
Int J Mol Sci. 2023 Mar 2;24(5):4819. doi: 10.3390/ijms24054819.
External ventricular drain(EVD) exposes the patient to infectious complications which are associated with significant morbidity and economic burden. Biomaterials impregnated with various antimicrobial agents have been developed to decrease the rate of bacterial colonization and subsequent infection. While promising, antibiotics and silver-impregnated EVD showed conflicting clinical results. The aim of the present review is to discuss the challenges associated with the development of antimicrobial EVD catheters and their effectiveness from the bench to the bedside.
脑室外引流（EVD）会使患者面临感染并发症的风险，这些并发症会导致严重的发病率和经济负担。为了降低细菌定植和随后感染的发生率，已经开发出了各种抗菌剂浸渍的生物材料。虽然有希望，但抗生素和银浸渍的 EVD 显示出相互矛盾的临床结果。本综述的目的是讨论与开发抗菌 EVD 导管相关的挑战及其从实验室到临床的有效性。
