Department of Anatomy, Medical Faculty, Siirt University, Siirt 56100, Turkey.
Department of Histology and Embryology, Medical Faculty, Siirt University, Siirt 56100, Turkey.
Molecules. 2023 Feb 25;28(5):2164. doi: 10.3390/molecules28052164.
We aimed to determine the potential damage mechanisms of exposure to widely used sodium hypochlorite (NaOCl) and the effects of on this exposure. Rats were divided into six groups: control, , 4% NaOCl, 4% NaOCl + , 15% NaOCl, and 15% NaOCl + . Serum and lung tissue samples were taken after applying NaOCl and by inhalation twice a day for 30 min for four weeks. The samples were examined biochemically (TAS/TOS), histopathologically, and immunohistochemically (TNF-α). In serum TOS values, the mean of 15% NaOCl was significantly higher than in 15% NaOCl + . This was the opposite in terms of serum TAS values. Histopathologically, there was a significant increase in lung injury in 15% NaOCl; significant improvement was observed in 15% NaOCl + . Immunohistochemically, there was a significant increase in TNF-α expression in both 4% NaOCl and 15% NaOCl; significant decreases were observed in both 4% NaOCl + and 15% NaOCl + . The use of sodium hypochlorite, which is harmful to the lungs and is widely used in homes and industries, should be limited. In addition, using essential oil by inhalation may protect against the harmful effects of sodium hypochlorite.
我们旨在确定广泛使用的次氯酸钠（NaOCl）暴露的潜在损伤机制，以及 对这种暴露的影响。大鼠被分为六组：对照组、 、4% NaOCl、4% NaOCl+ 、15% NaOCl 和 15% NaOCl+ 。在通过吸入每天两次暴露于 NaOCl 和 30 分钟 4 周后，采集血清和肺组织样本。通过生化（TAS/TOS）、组织病理学和免疫组织化学（TNF-α）检查样本。在血清 TOS 值中，4% NaOCl 的平均值明显高于 15% NaOCl。而血清 TAS 值则相反。组织病理学上，15% NaOCl 导致肺损伤明显增加；在 15% NaOCl+ 中观察到明显改善。免疫组织化学上，4% NaOCl 和 15% NaOCl 中 TNF-α的表达明显增加；在 4% NaOCl+ 和 15% NaOCl+ 中观察到明显下降。应限制使用对肺部有害且在家庭和工业中广泛使用的次氯酸钠。此外，通过吸入 精油可能会保护免受次氯酸钠的有害影响。
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