College of Food Science and Technology, Guangdong Ocean University, Guangdong Provincial Key Laboratory of Aquatic Product Processing and Safety, Zhanjiang 524088, China.
College of Food Science and Technology, Nanjing Agricultural University, National Center of Meat Quality and Safety Control, Nanjing 210095, China.
Nutrients. 2023 Feb 21;15(5):1069. doi: 10.3390/nu15051069.
Systemic low-grade inflammation induced by unhealthy diet has become a common health concern as it contributes to immune imbalance and induces chronic diseases, yet effective preventions and interventions are currently unavailable. The L. flower (CIF) is a common herb with a strong anti-inflammatory effect in drug-induced models, based on the theory of "medicine and food homology". However, its effects and mechanisms in reducing food-induced systemic low-grade inflammation (FSLI) remain unclear. This study showed that CIF can reduce FSLI and represents a new strategy to intervene in chronic inflammatory diseases. In this study, we administered capsaicin to mice by gavage to establish a FSLI model. Then, three doses of CIF (7, 14, 28 g·kg·day) were tested as the intervention. Capsaicin was found to increase serum TNF-α levels, demonstrating a successful model induction. After a high dose of CIF intervention, serum levels of TNF-α and LPS were reduced by 62.8% and 77.44%. In addition, CIF increased the α diversity and number of OTUs in the gut microbiota, restored the abundance of and increased the total content of SCFAs in the feces. In summary, CIF inhibits FSLI by modulating the gut microbiota, increasing SCFAs levels and inhibiting excessive LPS translocation into the blood. Our findings provided a theoretical support for using CIF in FSLI intervention.
不健康饮食引起的全身性低度炎症已成为一个常见的健康问题，因为它会导致免疫失衡并引发慢性疾病，但目前还没有有效的预防和干预措施。根据“药食同源”理论，L. flower（CIF）是一种常见的草药，在药物诱导的模型中具有很强的抗炎作用。然而，其在减轻饮食诱导的全身性低度炎症（FSLI）方面的作用和机制尚不清楚。本研究表明，CIF 可以减轻 FSLI，代表了一种干预慢性炎症性疾病的新策略。在这项研究中，我们通过灌胃给小鼠施用辣椒素来建立 FSLI 模型。然后，我们测试了三种剂量的 CIF（7、14、28 g·kg·day）作为干预措施。发现辣椒素可增加血清 TNF-α 水平，表明成功诱导了模型。高剂量 CIF 干预后，血清 TNF-α 和 LPS 水平分别降低了 62.8%和 77.44%。此外，CIF 增加了肠道微生物群的α多样性和 OTU 数量，恢复了的丰度，并增加了粪便中 SCFAs 的总量。总之，CIF 通过调节肠道微生物群、增加 SCFAs 水平和抑制 LPS 过度易位进入血液来抑制 FSLI。我们的研究结果为使用 CIF 干预 FSLI 提供了理论支持。
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