Clinical Department of Internal Medicine and Gastroenterology with Inflammatory Bowel Disease Unit, National Medical Institute of the Ministry of the Inferior and Administration, 02-507 Warsaw, Poland.
Department of Internal Medicine, Endocrinology and Diabetology, National Medical Institute of the Ministry of the Inferior and Administration, 02-507 Warsaw, Poland.
Nutrients. 2023 Feb 24;15(5):1151. doi: 10.3390/nu15051151.
There are many known risk factors for osteoporosis (OST) among patients with inflammatory bowel disease (IBD), one of which is physical activity.
The aim of the study is to assess the frequency and risk factors of OST among 232 patients with IBD compared to a group of 199 patients without IBD. The participants underwent dual-energy X-ray absorptiometry, laboratory tests, and completed a questionnaire about their physical activity.
It was found that 7.3% of IBD patients suffered from OST. Male gender, ulcerative colitis, extensive inflammation in the intestine, exacerbation of disease, rare physical activity, other forms of physical activity, past fractures, lower levels of osteocalcin, and higher levels of C-terminal telopeptide of type 1 collagen were risk factors for OST. As many as 70.6% of OST patients were rarely physically active.
OST is a common problem in IBD patients. OST risk factors differ significantly between the general population and those with IBD. Modifiable factors can be influenced by patients and by physicians. The key to OST prophylaxis may be regular physical activity, which should be recommended in clinical remission. It may also prove valuable to use markers of bone turnover in diagnostics, which may enable decisions regarding therapy.
炎症性肠病（IBD）患者存在许多已知的骨质疏松症（OST）风险因素，其中之一是身体活动。
本研究旨在评估 232 例 IBD 患者与 199 例无 IBD 患者相比，OST 的发生频率和危险因素。参与者接受了双能 X 射线吸收法、实验室检查，并完成了一份关于身体活动的问卷。
发现 7.3%的 IBD 患者患有 OST。男性、溃疡性结肠炎、肠道广泛炎症、疾病加重、罕见的体力活动、其他形式的体力活动、既往骨折、骨钙素水平较低、1 型胶原 C 端肽水平较高是 OST 的危险因素。多达 70.6%的 OST 患者很少进行体力活动。
OST 是 IBD 患者的常见问题。OST 的危险因素在普通人群和 IBD 患者之间有显著差异。可改变的因素可以由患者和医生共同影响。OST 预防的关键可能是定期进行体力活动，这应在临床缓解期得到推荐。在诊断中使用骨转换标志物可能也具有价值，这可能有助于决定治疗方案。
