来自海洋海绵 de Laubenfels 的 hipposponols A 和 B，两种新的 9,11-甾醇。
Hipposponols A and B, two new 9, 11-secosterols from the marine sponge de Laubenfels.
机构信息
School of Food and Pharmacy, Zhejiang Ocean University, Zhoushan, China.
Research Center for Marine Drugs, State Key Laboratory of Oncogenes and Related Genes, Department of Pharmacy, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.
出版信息
Nat Prod Res. 2024 Aug;38(15):2562-2568. doi: 10.1080/14786419.2023.2188588. Epub 2023 Mar 10.
Two new 9,11-secosterols, hipposponols A () and B (), together with five known analogues, aplidiasterol B (), (3,5,6)-3,5,6-triol-cholest-7-ene (), (3,5,6,22)-3,5,6-triol-ergosta-7,22-diene (), and one pair of inseparable C-24 epimers of (3,5,6,22E)-3,5,6-triol-stigmasta-7,22-diene (/), were isolated from the marine sponge de Laubenfels. The structures of isolated compounds were extensively elucidated based on HRESIMS and NMR data. Compounds - showed cytotoxicity against PC9 cells with IC values ranging from 34.1 ± 0.9 to 38.9 ± 1.0 µM and compound displayed cytotoxicity against MCF-7 cells with IC value of 39.0 ± 0.4 µM.
从海洋海绵中分离得到两种新的 9,11- 甾醇 hipposponols A () 和 B (), 以及 5 种已知类似物 aplidiasterol B (), (3,5,6)-3,5,6-三醇-胆甾-7-烯 (), (3,5,6,22)-3,5,6-三醇-麦角甾-7,22-二烯 (), 和一对不可分离的 C-24 差向异构体 (3,5,6,22E)-3,5,6-三醇-豆甾-7,22-二烯 (/). 基于 HRESIMS 和 NMR 数据，对分离得到的化合物的结构进行了广泛的阐明。化合物 - 对 PC9 细胞具有细胞毒性，IC 值范围为 34.1±0.9 至 38.9±1.0 μM，化合物 对 MCF-7 细胞具有细胞毒性，IC 值为 39.0±0.4 μM。
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