Department of Biology, Faculty of Science and Health, Koya University, Koya KOY45, Kurdistan Region - F.R. Iraq.
Cell Mol Biol (Noisy-le-grand). 2022 Sep 30;68(9):171-178. doi: 10.14715/cmb/2022.68.9.27.
The measurement of anti-Müllerian hormone (AMH), which is released in the serum and seminal fluid is a specific indicator of Sertoli cell function. This study aimed to evaluate AMH as a potential clinical indicator of infertility in males with normal and low sperm concentrations, as well as those with primary and secondary infertility. It was a retrospective analysis of 140 males chosen from sole infertility and IVF center in Erbil. without a known cause of infertility, 40 men with normal sperm counts, 100 men with primary, and 40 men with secondary infertility were assessed. An in-house ELISA was used to assess the serum AMH. Semen parameters, Semen and sera cytokines, and certain sex hormone mean levels were compared and correlated with AMH as the primary outcome measures. Seminal and serum AMH levels in infertile males were significantly lower. While an insignificant correlation was detected between AMH and LH, prolactin, or testosterone in azoospermic men, there was a significant adverse association between seminal AMH and FSH. A substantial positive association between seminal AMH and testosterone was found in oligospermia men, although no significant correlations were observed with FSH, LH, or prolactin. In conclusion, AMH in seminal plasma is a reliable marker of male infertility with a role in sperm production.
抗苗勒管激素（AMH）的测量，这种激素在血清和精液中释放，是支持细胞功能的特异性指标。本研究旨在评估 AMH 作为正常和低精子浓度、原发性和继发性不育男性不育潜在临床指标的可能性。这是对来自埃尔比勒唯一不孕和试管婴儿中心的 140 名男性进行的回顾性分析。这些男性没有已知的不孕原因，其中 40 名精子计数正常，100 名原发性不育，40 名继发性不育。采用内部 ELISA 评估血清 AMH。比较精液参数、精液和血清细胞因子以及某些性激素平均水平，并将其与 AMH 作为主要结果指标进行相关性分析。不育男性的精液和血清 AMH 水平显著降低。虽然在无精子症男性中，AMH 与 LH、催乳素或睾酮之间未检测到显著相关性，但在少精子症男性中，精液 AMH 与 FSH 之间存在显著的负相关关系。在少精子症男性中，发现精液 AMH 与睾酮之间存在显著的正相关关系，尽管与 FSH、LH 或催乳素之间未观察到显著相关性。总之，精液中的 AMH 是男性不育的可靠标志物，在精子生成中起作用。
