Osipova O A, Gosteva E V, Klyuchnikov N I, Khachaturov A N, Lykov Y A, Plaksina K G
Belgorod State National Research University, 85 Pobedy str., Belgorod 308015, Russian Federation, e-mail:
Adv Gerontol. 2022;35(6):856-861.
The aim of the study was to assess cognitive functions, anxiety and depression in elderly patients with arterial hypertension (AH) who had an ischemic stroke, depending on whether they had chronic kidney disease (CKD). 170 elderly patients with hypertension who had an ischemic stroke were examined, 90 of them had CKD C1-2. The average age is 70,2±2,6 years. The control group consisted of 60 middle-aged patients who had suffered an ischemic stroke without CKD. It was found that elderly patients with hypertension who suffered an ischemic stroke without CKD had a violation of constructive praxis (18,5%, p<0,01), reduced ability to verbal communication (18,3%, p<0,01), information comparison, inference (15,2%, p<0,05), weakening of auditory-speech memory, visual images (23,9%, p<0,01) compared to the control group. In the presence of CKD, patients had a reduced understanding of reversed speech, its fluency (14,2%, p<0,05), decreased intelligence, ability to compare information, make conclusions (8,6%, p<0,05), decreased memory (19,4%, p<0,01) compared with the group without CKD. Patients with hypertension who had an ischemic stroke in the presence of CKD had higher rates of occurrence of depressive episodes (21,5%, p<0,01), anxiety level (17,6%, p<0,01) and average depression score (22,2%, p<0,01) than without CKD. Thus, in elderly patients with hypertension who had an ischemic stroke in the presence of CKD, an increase in the frequency and severity of cognitive impairment (according to the MoCA scale), depression (according to GDS), a higher level of anxiety (according to the STAI) compared with elderly patients with hypertension who had an ischemic stroke without CKD was revealed.