抗糖单克隆抗体：基础研究与临床应用。
Anti-glycan monoclonal antibodies: Basic research and clinical applications.
机构信息
Chemical Biology Laboratory, Center for Cancer Research, National Cancer Institute, Frederick, MD, 21702, USA.
Chemical Biology Laboratory, Center for Cancer Research, National Cancer Institute, Frederick, MD, 21702, USA.
出版信息
Curr Opin Chem Biol. 2023 Jun;74:102281. doi: 10.1016/j.cbpa.2023.102281. Epub 2023 Mar 9.
Abstract
Anti-glycan monoclonal antibodies have important applications in human health and basic research. Therapeutic antibodies that recognize cancer- or pathogen-associated glycans have been investigated in numerous clinical trials, resulting in two FDA-approved biopharmaceuticals. Anti-glycan antibodies are also utilized to diagnose, prognosticate, and monitor disease progression, as well as to study the biological roles and expression of glycans. High-quality anti-glycan mAbs are still in limited supply, highlighting the need for new technologies for anti-glycan antibody discovery. This review discusses anti-glycan monoclonal antibodies with applications to basic research, diagnostics, and therapeutics, focusing on recent advances in mAbs targeting cancer- and infectious disease-associated glycans.
摘要
抗糖单克隆抗体在人类健康和基础研究中有重要应用。识别癌症或病原体相关糖的治疗性抗体已在许多临床试验中进行了研究，导致了两种获得 FDA 批准的生物制药。抗糖抗体也用于诊断、预后和监测疾病进展，以及研究糖的生物学作用和表达。高质量的抗糖 mAb 仍然供应有限，这凸显了需要新的抗糖抗体发现技术。本文综述了抗糖单克隆抗体在基础研究、诊断和治疗中的应用，重点介绍了针对癌症和传染病相关糖的 mAb 的最新进展。
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