暴露于旋转磁场作为一种增加活性药物成分皮肤渗透性的方法。

Exposure to a rotating magnetic field as a method of increasing the skin permeability of active pharmaceutical ingredients.

作者信息

Rakoczy Rafał, Nowak Anna, Konopacki Maciej, Kordas Marian, Kucharski Łukasz, Ossowicz-Rupniewska Paula

机构信息

West Pomeranian University of Technology in Szczecin, Faculty of Chemical Technology and Engineering, Department of Chemical and Process Engineering, Piastów Ave. 42, 71-065 Szczecin, Poland.

Pomeranian Medical University in Szczecin, Department of Cosmetic and Pharmaceutical Chemistry, Powstańców Wielkopolskich Ave. 72, 70-111 Szczecin, Poland.

出版信息

Eur J Pharm Biopharm. 2023 Apr;185:183-189. doi: 10.1016/j.ejpb.2023.02.017. Epub 2023 Mar 10.

DOI:10.1016/j.ejpb.2023.02.017

PMID:36905969

Abstract

The paper presents a method of increasing the permeability of various active substances through the skin by means of a rotating magnetic field. The study used 50 Hz RMF and various active pharmaceutical ingredients (APIs) such as caffeine, ibuprofen, naproxen, ketoprofen, and paracetamol. Various concentrations of active substance solutions in ethanol were used in the research, corresponding to those in commercial preparations. Each experiment was conducted for 24 h. It was shown that, regardless of the active compound used, an increase in drug transport through the skin was observed with RMF exposure. Furthermore, the release profiles depended on the active substance used. Exposure to a rotating magnetic field has been shown to effectively increase the permeability of an active substance through the skin.

摘要

本文提出了一种通过旋转磁场提高各种活性物质经皮渗透性的方法。该研究使用了50Hz的旋转磁场以及多种活性药物成分（API），如咖啡因、布洛芬、萘普生、酮洛芬和对乙酰氨基酚。研究中使用了乙醇中不同浓度的活性物质溶液，其浓度与市售制剂中的浓度相对应。每个实验进行24小时。结果表明，无论使用何种活性化合物，在暴露于旋转磁场时均观察到药物经皮转运增加。此外，释放曲线取决于所使用的活性物质。已证明暴露于旋转磁场可有效提高活性物质经皮的渗透性。