Hazt Bianca, Pereira Parchen Gabriela, Fernanda Martins do Amaral Lilian, Rondon Gallina Patrícia, Martin Sandra, Hess Gonçalves Odinei, Alves de Freitas Rilton
Chemistry Department, Universidade Federal do Paraná (UFPR), R. Coronel F. H. dos Santos, 210, Curitiba - 81531-980, PR, Brazil.
Department of Pharmacy, Universidade Federal do Paraná (UFPR), Av. Pref. Lothário Meissner, 632, Curitiba - 80210-170, PR, Brazil.
Int J Pharm. 2023 Apr 5;636:122817. doi: 10.1016/j.ijpharm.2023.122817. Epub 2023 Mar 9.
Pickering emulsions are free from molecular and classical surfactants and are stabilized by solid particles, creating long-term stability against emulsion coalescence. Additionally, these emulsions are both environmentally and skin-friendly, creating new and unexplored sensorial perceptions. Although the literature mostly describes conventional emulsions (oil-in-water), there are unconventional emulsions (multiple, oil-in-oil and water-in-water) with excellent prospects and challenges in skin application as oil-free systems, permeation enhancers and topical drug delivery agents, with various possibilities in pharmaceutical and cosmetic products. However, up to now, these conventional and unconventional Pickering emulsions are not yet available as commercial products. This review brings to the discussion some important aspects such as the use of phases, particles, rheological and sensorial perception, as well as current trends in the development of these emulsions.
皮克林乳液不含分子表面活性剂和传统表面活性剂，由固体颗粒稳定，具有长期抗乳液聚结稳定性。此外，这些乳液对环境和皮肤都友好，能带来全新且未被探索的感官体验。尽管文献大多描述的是传统乳液（水包油型），但也存在非传统乳液（多重乳液、油包油型和水包水型），它们作为无油体系、渗透促进剂和局部给药载体在皮肤应用方面有着极好的前景和挑战，在制药和化妆品领域有多种可能性。然而，截至目前，这些传统和非传统的皮克林乳液尚未作为商业产品面世。本综述讨论了一些重要方面，如相的使用、颗粒、流变学和感官感受，以及这些乳液的当前发展趋势。
