Department of Neurosurgery, Renmin Hospital of Wuhan University, Wuhan, China.
Department of Thoracic Surgery, Renmin Hospital of Wuhan University, Wuhan, China.
Genomics. 2023 May;115(3):110602. doi: 10.1016/j.ygeno.2023.110602. Epub 2023 Mar 11.
Glioma is the most common primary tumor in the human central nervous system. This study was designed to explore the expression of BZW1 in glioma and its relevance to the clinicopathological features and outcome of glioma patients.
Glioma transcription profiling data were obtained from The Cancer Genome Atlas (TCGA). TIMER2, GEPIA2, GeneMANIA, and Metascape were searched in the present study. Cell and animal experiments were conducted to verify the effect of BZW1 on glioma cell migration in vitro and in vivo. Transwell assays, western blotting and immunofluorescence assays were performed.
We found that BZW1 was highly expressed in gliomas and correlated with poor prognosis. BZW1 could promote glioma proliferation. GO/KEGG analysis revealed that BZW1 was involved in collagen-containing extracellular matrix and was correlated with ECM-receptor interactions, transcriptional misregulation in cancer and the IL-17 signaling pathway. In addition, BZW1 was also associated with the glioma tumor immune microenvironment.
BZW1 can promote glioma proliferation and progression, and its high expression is correlated with a poor prognosis. BZW1 is also associated with the tumor immune microenvironment of glioma. This study may facilitate further understanding of the critical role of BZW1 in human tumors, including gliomas.
脑胶质瘤是人类中枢神经系统最常见的原发性肿瘤。本研究旨在探讨 BZW1 在脑胶质瘤中的表达及其与脑胶质瘤患者临床病理特征和预后的关系。
本研究从癌症基因组图谱（TCGA）中获取脑胶质瘤转录组学数据。在本研究中，使用了 TIMER2、GEPIA2、GeneMANIA 和 Metascape 进行搜索。通过细胞和动物实验，验证了 BZW1 对体外和体内脑胶质瘤细胞迁移的影响。进行了 Transwell 检测、western blot 和免疫荧光实验。
我们发现 BZW1 在脑胶质瘤中高表达，与预后不良相关。BZW1 可以促进脑胶质瘤的增殖。GO/KEGG 分析表明，BZW1 参与了富含胶原蛋白的细胞外基质，并与 ECM-受体相互作用、癌症转录失调和 IL-17 信号通路相关。此外，BZW1 还与脑胶质瘤肿瘤免疫微环境相关。
BZW1 可以促进脑胶质瘤的增殖和进展，其高表达与预后不良相关。BZW1 还与脑胶质瘤的肿瘤免疫微环境相关。本研究可能有助于进一步了解 BZW1 在包括脑胶质瘤在内的人类肿瘤中的关键作用。
