日本斑点热和斑疹伤寒群立克次体感染之间的血清学交叉反应性。

Serological cross-reactivity between spotted fever and typhus groups of rickettsia infection in Japan.

作者信息

Aita Tetsuro, Sando Eiichiro, Katoh Shungo, Hamaguchi Sugihiro, Fujita Hiromi, Kurita Noriaki

机构信息

Department of General Internal Medicine, Fukushima Medical University, Fukushima, Japan; Department of Clinical Epidemiology, Graduate School of Medicine, Fukushima Medical University, Fukushima, Japan.

Department of General Internal Medicine and Clinical Infectious Diseases, Fukushima Medical University, Fukushima, Japan; Department of General Internal Medicine and Infectious Diseases, Kita-Fukushima Medical Center, Fukushima, Japan; Institute of Rickettsioses, Kita-Fukushima Medical Center, Fukushima, Japan.

出版信息

Int J Infect Dis. 2023 May;130:178-181. doi: 10.1016/j.ijid.2023.03.012. Epub 2023 Mar 11.

DOI:10.1016/j.ijid.2023.03.012

PMID:36907548

Abstract

OBJECTIVES

We examined the frequency of cross-reactions to Rickettsia typhi in patients with Japanese spotted fever (JSF) and evaluated the differences between two rickettsiae using antibody endpoint titers.

METHODS

Patients' immunoglobulin (Ig)M and IgG titers against Rickettsia japonica and Rickettsia typhi in two phases were measured using an indirect immunoperoxidase assay at two reference centers for rickettsiosis in Japan. Cross-reaction was defined as a higher titer against R. typhi in convalescent sera than in acute sera among patients fulfilling the criteria for JSF diagnosis. The frequencies of IgM and IgG were also evaluated.

RESULTS

Approximately 20% of cases showed positive cross-reactions. A comparison of antibody titers revealed the difficulty in identifying some positive cases.

CONCLUSION

Cross-reactions of 20% in serodiagnosis may lead to the misclassification of rickettsial diseases. However, with the exception of some cases, we were able to successfully differentiate JSF from murine typhus using each endpoint titer.

摘要