墨西哥尤卡坦半岛疑似患结核病的人群中的恙虫病东方体和嗜吞噬细胞无形体血清阳性情况。

SFG and TG seropositivity in Humans suspected of TBD in Yucatan, Mexico.

作者信息

Dzul Rosado Karla Rossanet, Peña Bates Carlos Aaron, Tello Martin Raúl, Noh-Pech Henry R, Puerto Fernando I, Omodior Oghenekaro

机构信息

Regional Research Center 'Dr. Hideyo Noguchi', Universidad Autónoma de Yucatan, Merida, Mexico.

Research Unit, Instituto Nacional de Enfermedades Respiratorias Ismael Cosío Villegas, Mexico City, Mexico.

出版信息

Epidemiol Infect. 2025 Jan 8;153:e21. doi: 10.1017/S0950268824001894.

DOI:10.1017/S0950268824001894

PMID:39773301

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11795441/

Abstract

Since 1996, the incidence of rickettsiosis has been increasing in Yucatán, Mexico, but recent prevalence data are lacking. This study aimed to determine exposure to the Spotted Fever Group (SFG) and Typhus Group (TG) in human serum samples suspected of tick-borne diseases (TBD) between 2015 and 2022. A total of 620 samples were analysed using indirect immunofluorescence assay (IFA) to detect IgG antibodies against SFG () and TG (), considering a titer of ≥64 as positive. Results showed that 103 samples (17%) were positive for and 145 (24%) for , while 256 (41%) and 229 (37%) were negative, respectively. There was a cross-reaction in 244 samples (39%). Individuals with contact with vectors, such as ticks, showed significant exposure to fleas (p = 0.0010). The study suggests a high prevalence of rickettsiosis and recommends prospective studies to assess the disease burden and strengthen surveillance and prevention in Yucatán, considering factors like temperature and ecological changes.

摘要

自1996年以来，墨西哥尤卡坦州立克次体病的发病率一直在上升，但缺乏近期的流行率数据。本研究旨在确定2015年至2022年间疑似蜱传疾病（TBD）的人类血清样本中感染斑点热群（SFG）和斑疹伤寒群（TG）的情况。使用间接免疫荧光测定法（IFA）对总共620份样本进行分析，以检测针对SFG（）和TG（）的IgG抗体，将滴度≥64视为阳性。结果显示，103份样本（17%）的呈阳性，145份样本（24%）的呈阳性，而分别有256份（41%）和229份（37%）为阴性。244份样本（39%）存在交叉反应。与蜱等媒介有接触的个体显示出明显的跳蚤暴露（p = 0.0010）。该研究表明立克次体病的流行率很高，并建议进行前瞻性研究，以评估疾病负担，并考虑温度和生态变化等因素，加强尤卡坦州的监测和预防工作。