罕见儿科非霍奇金淋巴瘤的诊断与治疗。

Diagnosis and management of rare paediatric Non-Hodgkin lymphoma.

机构信息

Division of Hematology and Oncology, Department of Pediatrics, University of Alabama at Birmingham, 1600 7(th) Avenue South, Lowder 512 Birmingham, AL, 35233, USA.

Department of Hematology and Oncology, Shimane University, 89-1 En-ya Cho, Izumo, 693-8501, Japan.

出版信息

Best Pract Res Clin Haematol. 2023 Mar;36(1):101440. doi: 10.1016/j.beha.2023.101440. Epub 2023 Jan 15.

DOI:10.1016/j.beha.2023.101440

PMID:36907633

Abstract

Mature B-cell lymphomas, (B- or T-cell) lymphoblastic lymphomas (LBL), and anaplastic large cell lymphoma (ALCL) correspond to about 90% of all non-Hodgkin lymphoma (NHL) cases occurring in children and adolescents. The remaining 10% encompass a complex group of entities characterized by low/very low incidences, paucity of knowledge in terms of underlying biology in comparison to their adult counterparts, and consequent lack of standardization of care, information on clinical therapeutic efficacy and long-term survival. At the Seventh International Symposium on Childhood, Adolescent and Young Adult NHL, organized on October 20-23, 2022, in New York City, New York, US, we had the opportunity to discuss clinical, pathogenetic, diagnostic, and treatment aspects of certain subtypes of rare B- or T-cell NHL and they will be the topic of this review.

摘要

成熟 B 细胞淋巴瘤（B 或 T 细胞）、淋巴母细胞淋巴瘤（LBL）和间变大细胞淋巴瘤（ALCL）约占儿童和青少年所有非霍奇金淋巴瘤（NHL）病例的 90%。其余 10%包括一组复杂的实体，其特征为发病率低/非常低，与成人相比，其基础生物学知识匮乏，因此缺乏护理标准、临床治疗效果和长期生存的信息。在 2022 年 10 月 20 日至 23 日于美国纽约市举行的第七届儿童、青少年和青年 NHL 国际研讨会上，我们有机会讨论某些罕见 B 或 T 细胞 NHL 亚型的临床、发病机制、诊断和治疗方面，它们将是本次综述的主题。