Chalfon Carmit, Finotello Riccardo, Sabattini Silvia, Gramer Irina, Morris Joanna Siriol, Aralla Marina, Morello Emanuela Maria, Ferraris Erica, Ramos Sofia, Polton Gerry, Schiavo Luca, Dobson Jane, Cola Veronica, Marconato Laura
Department of Veterinary Medical Sciences, University of Bologna, Ozzano dell'Emilia, Italy.
Department of Small Animal Clinical Science, School of Veterinary Science, Institute of Infection, Veterinary and Ecological Sciences, University of Liverpool, Neston, UK.
Vet Comp Oncol. 2023 Jun;21(2):332-338. doi: 10.1111/vco.12893. Epub 2023 Mar 21.
Canine cutaneous mast cell tumours (cMCTs) of the pinna have been associated with an aggressive biological behaviour, although data remain scarce. The knowledge acquired over the past years on histologic gradings, and the value of lymph node (LN) staging, may help in better characterizing this anatomical presentation. The first aim was to describe the frequency, location, and histologic appearance of LN metastases in cMCT of the pinna. A second aim was to evaluate prognosis. Medical records of dogs with cMCT of the pinna, that underwent tumour and sentinel (SLN) or regional LN (RLN) excision, were reviewed. The influence of potential prognostic variables on time to progression (TTP) and tumour-specific survival (TSS) was investigated. Thirty-nine dogs were included: 19 (48.7%) had Kiupel high-grade (K-HG) and 20 (51.3%) had low-grade (K-LG) MCTs. Eighteen (46.1%) dogs underwent SLN mapping: the superficial cervical LN was at least one of SLN in 17 (94.4%) cases. Twenty-two (56.4%) dogs had LN metastases; the superficial cervical LN was always involved. On multivariable analysis, only K-HG was associated with increased risk of progression (p = .043) and tumour-related death (p = .021). Median TTP and TSS were 270 and 370 days in K-HG, respectively; these were not reached in dogs with K-LG tumours (p < .01). cMCTs of the pinna are often K-HG and are also associated with a higher frequency of LN metastasis; however, we confirmed the independent prognostic value of histologic grading. A multimodal treatment may lead to favourable long-term outcome. Moreover, the superficial cervical LN is most often the SLN.
耳廓犬皮肤肥大细胞瘤（cMCTs）虽相关数据仍较少，但一直被认为具有侵袭性生物学行为。过去几年所获得的关于组织学分级以及淋巴结（LN）分期价值的知识，可能有助于更好地描述这种解剖学表现。第一个目的是描述耳廓cMCT中LN转移的频率、位置和组织学表现。第二个目的是评估预后。回顾了接受肿瘤和前哨淋巴结（SLN）或区域淋巴结（RLN）切除的耳廓cMCT犬的病历。研究了潜在预后变量对进展时间（TTP）和肿瘤特异性生存（TSS）的影响。纳入了39只犬：19只（48.7%）患有Kiupel高级别（K-HG），20只（51.3%）患有低级别（K-LG）MCT。18只（46.1%）犬进行了SLN定位：17只（94.4%）病例中，颈浅淋巴结至少是一个SLN。22只（56.4%）犬有LN转移；颈浅淋巴结总是受累。多变量分析显示，只有K-HG与进展风险增加（p = 0.043）和肿瘤相关死亡（p = 0.021）相关。K-HG的中位TTP和TSS分别为270天和370天；K-LG肿瘤犬未达到这些值（p < 0.01）。耳廓cMCT通常为K-HG，且LN转移频率也较高；然而，我们证实了组织学分级的独立预后价值。多模式治疗可能导致良好的长期结果。此外，颈浅淋巴结最常是SLN。
