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出于肿瘤学和社会原因的卵母细胞玻璃化冷冻保存

Oocyte vitrification for oncological and social reasons.

作者信息

Köroğlu Nadiye, Aydın Turgut

机构信息

Acıbadem Atakent Hospital, Clinic of Obstetrics and Gynecology, In Vitro Fertilization Unit, İstanbul, Turkey.

Acıbadem Mehmet Ali Aydınlar University, Atakent Hospital, Clinic of Obstetrics and Gynecology, In Vitro Fertilization Unit, İstanbul, Turkey.

出版信息

Turk J Obstet Gynecol. 2023 Mar 10;20(1):59-63. doi: 10.4274/tjod.galenos.2022.59827.

Abstract

The aim of this review is to present information related to oocyte cryopreservation, and particularly oocyte vitrification, performed to preserve fertility in oncologic and social indications. The success rates of oocyte cryopreservation have increased with the widespread use of the vitrification technique and are currently similar to those of in vitro fertilization performed with fresh oocytes. Vitrification is the most successful technique for oocyte cryopreservation. The most important factors that influence the success rate are the patient's age at the time of vitrification and the number of mature oocytes frozen. Thus, live birth rates differ for each age depending on the number of oocytes thawed and the freezing method. The American Society of Reproductive Medicine and the American Society of Clinical Oncology recommend presenting the option of oocyte cryopreservation for fertility preservation in cancer patients. Besides cancer patients, use of oocyte vitrification is increasing in women who wish to postpone pregnancy age and to have reproductive freedom with the development of the cryopreservation technique and the achievement of pregnancy rates similar to the use of fresh oocytes. Patients are provided consultancy service in terms of indication, the success rates by age, and the total number of oocytes frozen. It should be emphasized that this procedure is not a type of insurance policy for fertility, especially in elective oocyte cryopreservation.

摘要

本综述的目的是介绍与卵母细胞冷冻保存相关的信息,尤其是卵母细胞玻璃化冷冻,其用于在肿瘤学和社会指征方面保存生育能力。随着玻璃化技术的广泛应用,卵母细胞冷冻保存的成功率有所提高,目前与使用新鲜卵母细胞进行体外受精的成功率相似。玻璃化冷冻是卵母细胞冷冻保存最成功的技术。影响成功率的最重要因素是玻璃化冷冻时患者的年龄以及冷冻的成熟卵母细胞数量。因此,根据解冻的卵母细胞数量和冷冻方法,每个年龄段的活产率有所不同。美国生殖医学学会和美国临床肿瘤学会建议为癌症患者提供卵母细胞冷冻保存以保留生育能力的选择。除癌症患者外,随着冷冻保存技术的发展以及实现与使用新鲜卵母细胞相似的妊娠率,希望推迟生育年龄并获得生育自由的女性对卵母细胞玻璃化冷冻的使用也在增加。在指征、各年龄段的成功率以及冷冻的卵母细胞总数方面为患者提供咨询服务。应当强调的是,这一程序并非生育的保险政策,尤其是在选择性卵母细胞冷冻保存方面。

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Oocyte vitrification for elective fertility preservation: the past, present, and future.
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