Kalra J, Hart I R
Department of Medicine, University of Ottawa, Ottawa Civic Hospital, Ontario, Canada.
Clin Biochem. 1987 Aug;20(4):265-7. doi: 10.1016/s0009-9120(87)80010-3.
We describe a sensitive thyrotropin (TSH) assay in the evaluation of thyroxine replacement therapy. Patients taking varying amounts of L-thyroxine replacement doses were studied using a thyrotropin-releasing hormone (TRH) test and a sensitive TSH assay as the indices of optimal replacement therapy. There were no differences in the mean thyroxine doses of those patients who had a normal TRH response and those who had a flat response. Similarly there were no significant differences in the serum free thyroxine (FT4), free triiodothyronine (FT3), or total triiodothyronine (TT3) levels between these two groups. The patients in both groups had normal basal serum TSH values as measured by a standard, HTSH RIABEAD (Abbott) method. However, serum TSH values, as measured by a sensitive TSH3 MAIACLONE (Serono) immunoradiometric method, were subnormal in all patients with flat TRH responses. The TSH (Serono) assay provided the best single blood test of optimal thyroxine replacement.
我们描述了一种用于评估甲状腺素替代治疗的敏感促甲状腺激素（TSH）检测方法。使用促甲状腺激素释放激素（TRH）试验和敏感TSH检测作为最佳替代治疗指标，对服用不同剂量L-甲状腺素替代药物的患者进行了研究。TRH反应正常的患者与反应平淡的患者在平均甲状腺素剂量方面没有差异。同样，这两组患者的血清游离甲状腺素（FT4）、游离三碘甲状腺原氨酸（FT3）或总三碘甲状腺原氨酸（TT3）水平也没有显著差异。两组患者通过标准的HTSH RIABEAD（雅培）方法测得的基础血清TSH值均正常。然而，通过敏感的TSH3 MAIACLONE（赛诺菲）免疫放射分析法测得的血清TSH值，在所有TRH反应平淡的患者中均低于正常水平。TSH（赛诺菲）检测为最佳甲状腺素替代治疗提供了最佳的单项血液检测。
