Yatscoff R W, Mehta A, Gerrard J M, Thliveris J
Department of Clinical Chemistry, University of Manitoba, Winnipeg, Canada.
Clin Biochem. 1987 Oct;20(5):359-63. doi: 10.1016/s0009-9120(87)80087-5.
The relationship of nonenzymatic glycation of platelet proteins to altered platelet function was studied in 33 diabetic patients. Platelets isolated from diabetic patients were glycated to a greater extent than those isolated from nondiabetic controls. No relationship was found between the level of glycation of platelets in diabetics to parameters commonly used to monitor glycemic control (glycated hemoglobin, glycated albumin, fasting blood glucose). Platelets isolated from diabetics did not show an increased level of aggregation and Thromboxane B2 production as compared to nondiabetic controls. No significant relationship was found between the level of glycation and percent aggregation of platelets. The lack of a relationship between glycation and aggregation suggests that the former may not be responsible for the functional changes in platelets seen in diabetics.
在33名糖尿病患者中研究了血小板蛋白的非酶糖基化与血小板功能改变之间的关系。从糖尿病患者中分离出的血小板比从非糖尿病对照组中分离出的血小板糖化程度更高。在糖尿病患者中，血小板的糖化水平与常用于监测血糖控制的参数（糖化血红蛋白、糖化白蛋白、空腹血糖）之间未发现相关性。与非糖尿病对照组相比，从糖尿病患者中分离出的血小板未显示出聚集水平和血栓素B2生成增加。在糖化水平与血小板聚集百分比之间未发现显著相关性。糖化与聚集之间缺乏相关性表明，前者可能不是导致糖尿病患者血小板功能变化的原因。
