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The dosing conundrum of emicizumab: To waste product or not?

作者信息

Young Guy

机构信息

Cancer and Blood Disorders Institute, Children's Hospital Los Angeles, University of Southern California Keck School of Medicine, Los Angeles, California, USA.

出版信息

Res Pract Thromb Haemost. 2023 Feb 16;7(2):100087. doi: 10.1016/j.rpth.2023.100087. eCollection 2023 Feb.

DOI:10.1016/j.rpth.2023.100087
PMID:36908771
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9999193/
Abstract
摘要

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本文引用的文献

1
The efficacy of the entire-vial dosing of emicizumab: Real-world evidence on plasma concentrations, bleeds, and drug waste.艾美赛珠单抗全瓶给药的疗效：关于血浆浓度、出血和药物浪费的真实世界证据。
Res Pract Thromb Haemost. 2023 Feb 8;7(2):100074. doi: 10.1016/j.rpth.2023.100074. eCollection 2023 Feb.
2
Long-term safety and efficacy of emicizumab for up to 5.8 years and patients' perceptions of symptoms and daily life: A phase 1/2 study in patients with severe haemophilia A.长达 5.8 年的依库珠单抗的长期安全性和疗效以及患者对症状和日常生活的认知：一项严重 A 型血友病患者的 1/2 期研究。
Haemophilia. 2021 Jan;27(1):81-89. doi: 10.1111/hae.14205. Epub 2020 Nov 24.
3
Pharmacokinetics and Pharmacodynamics of Emicizumab in Persons with Hemophilia A with Factor VIII Inhibitors: HAVEN 1 Study.Emicizumab 在有因子 VIII 抑制剂的血友病 A 患者中的药代动力学和药效学：HAVEN 1 研究。
Thromb Haemost. 2021 Mar;121(3):351-360. doi: 10.1055/s-0040-1717114. Epub 2020 Oct 21.
4
Effects of emicizumab on APTT, one-stage and chromogenic assays of factor VIII in artificially spiked plasma and in samples from haemophilia A patients with inhibitors.依库珠单抗对人工添加因子 VIII 的血浆标本和有抑制物的血友病 A 患者样本的 APTT、一步法及显色法检测因子 VIII 的影响。
Haemophilia. 2020 May;26(3):536-542. doi: 10.1111/hae.13990. Epub 2020 Apr 6.
5
Subcutaneous concizumab prophylaxis in hemophilia A and hemophilia A/B with inhibitors: phase 2 trial results.皮下康西珠单抗预防治疗 A 型血友病和有抑制剂的 A/B 型血友病：2 期临床试验结果。
Blood. 2019 Nov 28;134(22):1973-1982. doi: 10.1182/blood.2019001542.
6
Efficacy, safety, and pharmacokinetics of emicizumab prophylaxis given every 4 weeks in people with haemophilia A (HAVEN 4): a multicentre, open-label, non-randomised phase 3 study.每4周给予艾美赛珠单抗预防治疗A型血友病患者的疗效、安全性及药代动力学（HAVEN 4）：一项多中心、开放标签、非随机3期研究
Lancet Haematol. 2019 Jun;6(6):e295-e305. doi: 10.1016/S2352-3026(19)30054-7. Epub 2019 Apr 16.
7
Emicizumab Prophylaxis in Patients Who Have Hemophilia A without Inhibitors.艾美赛珠单抗预防无抑制剂的血友病 A 患者出血。
N Engl J Med. 2018 Aug 30;379(9):811-822. doi: 10.1056/NEJMoa1803550.
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Emicizumab Prophylaxis in Hemophilia A with Inhibitors.依库珠单抗预防伴抑制物的血友病 A。
N Engl J Med. 2017 Aug 31;377(9):809-818. doi: 10.1056/NEJMoa1703068. Epub 2017 Jul 10.