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异位分泌完整甲状旁腺激素（PTH）所致的恶性高钙血症。

Malignant Hypercalcemia Induced by the Ectopic Production of Intact Parathyroid Hormone (PTH).

作者信息

Neves Ana, Mendonça Inês, Cunha Marques José Alberto, Costa José, Almeida Jorge S

机构信息

Internal Medicine, Centro Hospitalar Universitário de São João, Porto, PRT.

Intensive Care Medicine, Centro Hospitalar Universitário de São João, Porto, PRT.

出版信息

Cureus. 2023 Feb 8;15(2):e34770. doi: 10.7759/cureus.34770. eCollection 2023 Feb.

DOI:10.7759/cureus.34770
PMID:36909108
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10001420/
Abstract

Malignant hypercalcemia is a common finding in patients with advanced cancer, involving mechanisms like tumor secretion of parathyroid hormone (PTH)-related protein, osteolytic metastases, and tumor production of calcitriol. Although rare, hypercalcemia induced by ectopic tumoral secretion of PTH can be an additional mechanism. Here we present an 84-year-old male patient who was admitted to the hospital with a non-productive cough, anorexia, and a single episode of small-volume hemoptysis. He was diagnosed with stage T4N3M1c left lung small cell carcinoma, and laboratory tests were remarkable for elevated ionized calcium as well as elevated serum intact PTH. A parathyroid 99mTc sestamibi scan showed no changes, suggesting ectopic production of PTH. Being a rare event, malignant hypercalcemia from intact PTH ectopic production should be considered in these patients.

摘要

恶性高钙血症是晚期癌症患者的常见表现，涉及肿瘤分泌甲状旁腺激素（PTH）相关蛋白、溶骨性转移以及肿瘤产生骨化三醇等机制。虽然由肿瘤异位分泌PTH引起的高钙血症较为罕见，但也可能是另一种机制。在此，我们报告一名84岁男性患者，因干咳、厌食和单次少量咯血入院。他被诊断为T4N3M1c期左肺小细胞癌，实验室检查显示离子钙升高以及血清完整PTH升高。甲状旁腺99mTc甲氧基异丁基异腈扫描未见异常，提示PTH异位产生。鉴于这种情况罕见，对于这些患者应考虑由完整PTH异位产生导致的恶性高钙血症。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/10bf/10001420/114891a3b3dd/cureus-0015-00000034770-i02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/10bf/10001420/71896dd3a34c/cureus-0015-00000034770-i01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/10bf/10001420/114891a3b3dd/cureus-0015-00000034770-i02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/10bf/10001420/71896dd3a34c/cureus-0015-00000034770-i01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/10bf/10001420/114891a3b3dd/cureus-0015-00000034770-i02.jpg

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J Endocr Soc. 2017 May 3;1(6):691-711. doi: 10.1210/js.2017-00063. eCollection 2017 Jun 1.
3
The IASLC Lung Cancer Staging Project: Proposals for Revision of the TNM Stage Groupings in the Forthcoming (Eighth) Edition of the TNM Classification for Lung Cancer.
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J Thorac Oncol. 2016 Jan;11(1):39-51. doi: 10.1016/j.jtho.2015.09.009.
4
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5
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6
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J Med Assoc Thai. 2007 Apr;90(4):663-71.
7
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8
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