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一组机械二尖瓣置换术后产妇病例:分娩期抗凝管理

A Case Series of Parturients With Mechanical Mitral Valves: Anticoagulation Management During Labor and Delivery.

作者信息

Nicholas Alexandra, Countouris Malamo, Jeyabalan Arun, Lim Grace

机构信息

Division of Obstetric and Women's Anesthesiology, Department of Anesthesiology and Perioperative Medicine, University of Pittsburgh School of Medicine, UPMC Magee Women's Hospital, Pittsburgh, Pennsylvania, USA.

Division of Cardiothoracic Anesthesiology, Department of Anesthesiology and Perioperative Medicine, University of Pittsburgh Medical Center, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA.

出版信息

JACC Case Rep. 2023 Mar 1;9:101741. doi: 10.1016/j.jaccas.2023.101741.

DOI:10.1016/j.jaccas.2023.101741
PMID:36909263
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9998718/
Abstract

More women with mechanical mitral valves (MMVs) are pursuing pregnancy. Guidelines exist for pregnancy anticoagulation, but they do not address individualized anticoagulation during delivery-a period of risk for bleeding, thrombosis, and anesthetic complications. This case series of parturients with MMVs highlights the challenges in, and the evidence and strategies for, treating these patients. ().

摘要

越来越多患有机械二尖瓣瓣膜(MMV)的女性选择怀孕。目前存在关于孕期抗凝的指南,但这些指南并未涉及分娩期间的个体化抗凝问题,而分娩期存在出血、血栓形成及麻醉并发症风险。本系列MMV产妇病例突出了治疗这些患者的挑战以及相关证据和策略。()

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8cf6/9998718/e699a10b6f8d/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8cf6/9998718/0e3de23bbd44/fx1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8cf6/9998718/e699a10b6f8d/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8cf6/9998718/0e3de23bbd44/fx1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8cf6/9998718/e699a10b6f8d/gr1.jpg

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本文引用的文献

1
Society for Maternal-Fetal Medicine Consult Series #61: Anticoagulation in pregnant patients with cardiac disease.母胎医学会咨询系列第 61 号:心脏病孕妇的抗凝治疗。
Am J Obstet Gynecol. 2022 Aug;227(2):B28-B43. doi: 10.1016/j.ajog.2022.03.036. Epub 2022 Mar 22.
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Obstetric Anesthesia and Heart Disease: Practical Clinical Considerations.产科麻醉与心脏病:实用临床考虑
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Cardiovascular Considerations in Caring for Pregnant Patients: A Scientific Statement From the American Heart Association.
妊娠期心血管问题的处理:美国心脏协会科学声明
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Pregnancy outcomes in women with mechanical prosthetic heart valves.机械心脏瓣膜置换术后女性的妊娠结局。
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The Society for Obstetric Anesthesia and Perinatology Consensus Statement on the Anesthetic Management of Pregnant and Postpartum Women Receiving Thromboprophylaxis or Higher Dose Anticoagulants.产科麻醉与围产医学学会关于接受血栓预防或高剂量抗凝药物治疗的妊娠和产后妇女的麻醉管理共识声明。
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7
Neuraxial Anesthesia in Obstetric Patients Receiving Thromboprophylaxis With Unfractionated or Low-Molecular-Weight Heparin: A Systematic Review of Spinal Epidural Hematoma.接受普通肝素或低分子量肝素进行血栓预防的产科患者的神经轴麻醉:关于脊髓硬膜外血肿的系统评价
Anesth Analg. 2017 Jul;125(1):223-231. doi: 10.1213/ANE.0000000000002173.
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Pregnancy outcomes in women with mechanical prosthetic heart valves: a prospective descriptive population based study using the United Kingdom Obstetric Surveillance System (UKOSS) data collection system.使用英国产科监测系统(UKOSS)数据收集系统,对机械人工心脏瓣膜女性的妊娠结局进行前瞻性描述性人群研究。
BJOG. 2017 Aug;124(9):1411-1419. doi: 10.1111/1471-0528.14478. Epub 2016 Dec 26.
9
Prosthetic Heart Valve Thrombosis.人工心脏瓣膜血栓形成。
J Am Coll Cardiol. 2016 Dec 20;68(24):2670-2689. doi: 10.1016/j.jacc.2016.09.958.
10
Practice Guidelines for Obstetric Anesthesia: An Updated Report by the American Society of Anesthesiologists Task Force on Obstetric Anesthesia and the Society for Obstetric Anesthesia and Perinatology.产科麻醉实践指南:美国麻醉医师协会产科麻醉特别工作组及产科麻醉与围产医学学会的最新报告。
Anesthesiology. 2016 Feb;124(2):270-300. doi: 10.1097/ALN.0000000000000935.