无重症肌无力的抗Kv1.4抗体：自身免疫性心肌炎和肌炎的罕见病因
Anti-Kv1.4 Antibody Without Myasthenia Gravis: A Rare Cause of Autoimmune Myocarditis and Myositis.
作者信息
Kuyama Naoto, Takashio Seiji, Nagakura Takumi, Imamura Michie, Takamatsu Koutaro, Takae Masafumi, Hirakawa Kyoko, Yamanaga Kenshi, Hanatani Shinsuke, Yamamoto Eiichiro, Matsushita Kenichi, Ueda Mitsuharu, Tsujita Kenichi
机构信息
Department of Cardiovascular Medicine, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan.
Department of Neurology, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan.
出版信息
JACC Case Rep. 2023 Jan 27;9:101734. doi: 10.1016/j.jaccas.2023.101734. eCollection 2023 Mar 1.
Anti-Kv1.4 antibody is often detected in thymoma-associated myasthenia gravis patients with anti-acetylcholine receptor antibody. Herein, we describe 2 patients with concurrent myocarditis and myositis. In both cases, anti-Kv1.4 antibody was positive despite the absence of thymoma and anti-acetylcholine receptor antibody, and immunosuppressants eventually resolved their symptoms and cardiac function. ().
抗Kv1.4抗体常在合并抗乙酰胆碱受体抗体的胸腺瘤相关重症肌无力患者中被检测到。在此，我们描述2例并发心肌炎和肌炎的患者。在这两例患者中，尽管没有胸腺瘤且抗乙酰胆碱受体抗体阴性，但抗Kv1.4抗体呈阳性，免疫抑制剂最终缓解了他们的症状和心脏功能。（）
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