• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

环甘氨酸-脯氨酸改善阿尔茨海默病APP/PS1转基因小鼠模型的记忆并减少淀粉样斑块负荷。

Cyclic Glycine-Proline Improves Memory and Reduces Amyloid Plaque Load in APP/PS1 Transgenic Mouse Model of Alzheimer's Disease.

作者信息

Arora Tushar, Sharma Shiv K

机构信息

National Brain Research Centre, Manesar, 122052 Haryana, India.

出版信息

Int J Alzheimers Dis. 2023 Mar 1;2023:1753791. doi: 10.1155/2023/1753791. eCollection 2023.

DOI:10.1155/2023/1753791
PMID:36909366
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9995210/
Abstract

Alzheimer's disease (AD) is a neurodegenerative condition that is pathologically characterized by the presence of amyloid plaques and neurofibrillary tangles. Animal models of AD have been useful in understanding the disease process and in investigating the effects of compounds on pathology and behavior. APP/PS1 mice develop amyloid plaques and show memory impairment. Cyclic glycine-proline (cGP) is a cyclic dipeptide that is likely produced from a tripeptide, glycine-proline-glutamate, which itself is generated after proteolytic cleavage of insulin-like growth factor-1. Here, we show that cGP improves spatial memory and reduces amyloid plaque burden in APP/PS1 mice. The results thus suggest that cGP could potentially provide beneficial effects in AD.

摘要

阿尔茨海默病（AD）是一种神经退行性疾病，其病理特征为存在淀粉样斑块和神经原纤维缠结。AD动物模型有助于理解疾病进程，并研究化合物对病理和行为的影响。APP/PS1小鼠会形成淀粉样斑块并表现出记忆障碍。环甘氨酸-脯氨酸（cGP）是一种环二肽，可能由三肽甘氨酸-脯氨酸-谷氨酸生成，而后者本身是胰岛素样生长因子-1经蛋白水解裂解后产生的。在此，我们表明cGP可改善APP/PS1小鼠的空间记忆并减轻淀粉样斑块负担。因此，结果表明cGP可能对AD具有有益作用。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/973d/9995210/99aa847d5282/IJAD2023-1753791.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/973d/9995210/70dce0f7d707/IJAD2023-1753791.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/973d/9995210/ed596fc10a64/IJAD2023-1753791.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/973d/9995210/99aa847d5282/IJAD2023-1753791.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/973d/9995210/70dce0f7d707/IJAD2023-1753791.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/973d/9995210/ed596fc10a64/IJAD2023-1753791.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/973d/9995210/99aa847d5282/IJAD2023-1753791.003.jpg

相似文献

1
Cyclic Glycine-Proline Improves Memory and Reduces Amyloid Plaque Load in APP/PS1 Transgenic Mouse Model of Alzheimer's Disease.环甘氨酸-脯氨酸改善阿尔茨海默病APP/PS1转基因小鼠模型的记忆并减少淀粉样斑块负荷。
Int J Alzheimers Dis. 2023 Mar 1;2023:1753791. doi: 10.1155/2023/1753791. eCollection 2023.
2
Effects of accelerated senescence on learning and memory, locomotion and anxiety-like behavior in APP/PS1 mouse model of Alzheimer's disease.加速衰老对阿尔茨海默病 APP/PS1 小鼠模型学习记忆、运动和焦虑样行为的影响。
J Neurol Sci. 2013 Dec 15;335(1-2):145-54. doi: 10.1016/j.jns.2013.09.018. Epub 2013 Sep 21.
3
Age-related changes in hippocampal AD pathology, actin remodeling proteins and spatial memory behavior of male APP/PS1 mice.雄性 APP/PS1 小鼠海马 AD 病理学、肌动蛋白重塑蛋白与空间记忆行为的年龄相关性变化。
Behav Brain Res. 2019 Dec 30;376:112182. doi: 10.1016/j.bbr.2019.112182. Epub 2019 Aug 28.
4
Metformin attenuates plaque-associated tau pathology and reduces amyloid-β burden in APP/PS1 mice.二甲双胍可减轻斑块相关的 tau 病理学改变，并降低 APP/PS1 小鼠的淀粉样-β负担。
Alzheimers Res Ther. 2021 Feb 9;13(1):40. doi: 10.1186/s13195-020-00761-9.
5
Liraglutide can reverse memory impairment, synaptic loss and reduce plaque load in aged APP/PS1 mice, a model of Alzheimer's disease.利拉鲁肽可逆转老年 APP/PS1 小鼠（阿尔茨海默病模型）的记忆障碍、突触丢失，并减少斑块负担。
Neuropharmacology. 2014 Jan;76 Pt A:57-67. doi: 10.1016/j.neuropharm.2013.08.005. Epub 2013 Aug 21.
6
Sex Differences in Neuropathology and Cognitive Behavior in APP/PS1/tau Triple-Transgenic Mouse Model of Alzheimer's Disease.阿尔茨海默病 APP/PS1/tau 三转基因小鼠模型中的神经病理学和认知行为的性别差异。
Neurosci Bull. 2018 Oct;34(5):736-746. doi: 10.1007/s12264-018-0268-9. Epub 2018 Aug 11.
7
Human gut microbiota Agathobaculum butyriciproducens improves cognitive impairment in LPS-induced and APP/PS1 mouse models of Alzheimer's disease.人肠道微生物 Agathobaculum butyriciproducens 改善脂多糖诱导和 APP/PS1 阿尔茨海默病小鼠模型的认知障碍。
Nutr Res. 2021 Feb;86:96-108. doi: 10.1016/j.nutres.2020.12.010. Epub 2020 Dec 9.
8
Glucose tolerance and insulin sensitivity are impaired in APP/PS1 transgenic mice prior to amyloid plaque pathogenesis and cognitive decline.在淀粉样斑块发病机制和认知衰退之前，APP/PS1转基因小鼠的葡萄糖耐量和胰岛素敏感性受损。
Exp Gerontol. 2017 Feb;88:9-18. doi: 10.1016/j.exger.2016.12.019. Epub 2016 Dec 23.
9
ApoA-I deficiency increases cortical amyloid deposition, cerebral amyloid angiopathy, cortical and hippocampal astrogliosis, and amyloid-associated astrocyte reactivity in APP/PS1 mice.载脂蛋白 A-I 缺乏症可增加 APP/PS1 小鼠皮质淀粉样沉积、脑淀粉样血管病、皮质和海马星形胶质细胞增生以及与淀粉样蛋白相关的星形胶质细胞反应性。
Alzheimers Res Ther. 2019 May 13;11(1):44. doi: 10.1186/s13195-019-0497-9.
10
The effect of focal brain injury on beta-amyloid plaque deposition, inflammation and synapses in the APP/PS1 mouse model of Alzheimer's disease.局灶性脑损伤对阿尔茨海默病APP/PS1小鼠模型中β-淀粉样蛋白斑块沉积、炎症和突触的影响。
Exp Neurol. 2015 May;267:219-29. doi: 10.1016/j.expneurol.2015.02.034. Epub 2015 Mar 4.

引用本文的文献

1
Reduction in Hippocampal Amyloid-β Peptide (Aβ) Content during Glycine-Proline-Glutamate (Gly-Pro-Glu) Co-Administration Is Associated with Changes in Inflammation and Insulin-like Growth Factor (IGF)-I Signaling.甘氨酸-脯氨酸-谷氨酸（Gly-Pro-Glu）共给药期间海马淀粉样β肽（Aβ）含量的减少与炎症和胰岛素样生长因子（IGF）-I 信号的变化有关。
Int J Mol Sci. 2024 May 24;25(11):5716. doi: 10.3390/ijms25115716.

本文引用的文献

1
Sinomenine inhibits amyloid beta-induced astrocyte activation and protects neurons against indirect toxicity.青藤碱抑制淀粉样β诱导的星形胶质细胞激活，保护神经元免受间接毒性。
Mol Brain. 2020 Mar 4;13(1):30. doi: 10.1186/s13041-020-00569-6.
2
Targeting Synaptic Plasticity in Experimental Models of Alzheimer's Disease.在阿尔茨海默病实验模型中靶向突触可塑性
Front Pharmacol. 2019 Jul 16;10:778. doi: 10.3389/fphar.2019.00778. eCollection 2019.
3
Graphene quantum dots conjugated neuroprotective peptide improve learning and memory capability.
石墨烯量子点偶联神经保护肽可改善学习记忆能力。
Biomaterials. 2016 Nov;106:98-110. doi: 10.1016/j.biomaterials.2016.08.021. Epub 2016 Aug 17.
4
Histone deacetylase inhibition facilitates massed pattern-induced synaptic plasticity and memory.组蛋白去乙酰化酶抑制作用促进集群模式诱导的突触可塑性和记忆。
Learn Mem. 2015 Sep 15;22(10):514-8. doi: 10.1101/lm.039289.115. Print 2015 Oct.
5
The role for IGF-1-derived small neuropeptides as a therapeutic target for neurological disorders.胰岛素样生长因子-1衍生的小神经肽作为神经疾病治疗靶点的作用。
Expert Opin Ther Targets. 2015 Jun;19(6):785-93. doi: 10.1517/14728222.2015.1010514. Epub 2015 Feb 5.
6
Development of a novel cellular model of Alzheimer's disease utilizing neurosphere cultures derived from B6C3-Tg(APPswe,PSEN1dE9)85Dbo/J embryonic mouse brain.利用源自B6C3-Tg(APPswe,PSEN1dE9)85Dbo/J胚胎小鼠脑的神经球培养物建立阿尔茨海默病新型细胞模型。
Springerplus. 2014 Mar 26;3:161. doi: 10.1186/2193-1801-3-161. eCollection 2014.
7
Insulin-like growth factor-1 and risk of Alzheimer dementia and brain atrophy.胰岛素样生长因子-1 与阿尔茨海默病痴呆和脑萎缩的风险。
Neurology. 2014 May 6;82(18):1613-9. doi: 10.1212/WNL.0000000000000382. Epub 2014 Apr 4.
8
Cyclic glycine-proline regulates IGF-1 homeostasis by altering the binding of IGFBP-3 to IGF-1.环状甘氨酸 - 脯氨酸通过改变胰岛素样生长因子结合蛋白3（IGFBP - 3）与胰岛素样生长因子1（IGF - 1）的结合来调节IGF - 1的稳态。
Sci Rep. 2014 Mar 17;4:4388. doi: 10.1038/srep04388.
9
Neural stem cell transplants improve cognitive function without altering amyloid pathology in an APP/PS1 double transgenic model of Alzheimer's disease.在阿尔茨海默病的APP/PS1双转基因模型中，神经干细胞移植可改善认知功能，而不改变淀粉样蛋白病理学特征。
Mol Neurobiol. 2014 Oct;50(2):423-37. doi: 10.1007/s12035-014-8640-x. Epub 2014 Jan 31.
10
Demonstrated brain insulin resistance in Alzheimer's disease patients is associated with IGF-1 resistance, IRS-1 dysregulation, and cognitive decline.阿尔茨海默病患者的脑胰岛素抵抗与 IGF-1 抵抗、IRS-1 失调和认知能力下降有关。
J Clin Invest. 2012 Apr;122(4):1316-38. doi: 10.1172/JCI59903.