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本文引用的文献

1
Proteasome Subunit Beta Type-8 (PSMB8) Gene Polymorphisms in Vitiligo: A Possible Predictor of Auditory Involvement.白癜风中蛋白酶体β亚基8型（PSMB8）基因多态性：听觉受累的一种可能预测指标
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2
Nuclear Factor Erythroid-2-related Factor 2 Gene Polymorphisms in Vitiligo.白癜风中核因子红细胞2相关因子2基因多态性
J Clin Aesthet Dermatol. 2021 Jun;14(6):14-17. Epub 2021 Jun 1.
3
DEFB1 gene polymorphisms modify vitiligo extent and response to NB-UVB phototherapy.DEFB1 基因多态性可改变白癜风的严重程度和对 NB-UVB 光疗的反应。
Dermatol Ther. 2021 May;34(3):e14921. doi: 10.1111/dth.14921. Epub 2021 Mar 7.
4
Association of GZMB polymorphisms and susceptibility to non-segmental vitiligo in a Korean population.GZMB 多态性与韩国人群中非节段性白癜风易感性的关联。
Sci Rep. 2021 Jan 11;11(1):397. doi: 10.1038/s41598-020-79705-0.
5
Factors affecting vitiligo response to treatment: do MiRNA 196a2C/T gene polymorphism and serum tyrosinase levels have any role?影响白癜风治疗反应的因素：miRNA196a2C/T 基因多态性和血清酪氨酸酶水平有作用吗？
J Dermatolog Treat. 2022 May;33(3):1351-1355. doi: 10.1080/09546634.2020.1810202. Epub 2020 Aug 24.
6
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Dermatology. 2020;236(6):571-592. doi: 10.1159/000506103. Epub 2020 Mar 10.
7
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8
Granzyme K Expressed by Classically Activated Macrophages Contributes to Inflammation and Impaired Remodeling.经典激活的巨噬细胞表达的颗粒酶 K 有助于炎症和重塑受损。
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Genetic polymorphisms of GZMB and vitiligo: A genetic association study based on Chinese Han population.GZMB 基因多态性与白癜风：基于中国汉族人群的遗传关联研究。
Sci Rep. 2018 Aug 29;8(1):13001. doi: 10.1038/s41598-018-31233-8.
10
Granzyme B in skin inflammation and disease.颗粒酶 B 与皮肤炎症和疾病。
Matrix Biol. 2019 Jan;75-76:126-140. doi: 10.1016/j.matbio.2017.12.005. Epub 2017 Dec 14.

颗粒酶B基因多态性与重度非节段型白癜风相关。

Granzyme B Gene Polymorphisms Are Associated With Severe Non-segmental Vitiligo.

作者信息

El-Taweel Abd El-Aziz, Abdelrahman Amira, Hegazy Hebatallah, Salem Rehab

机构信息

Dr. El-Taweel is with Faculty of Medicine at 6th of October University in Cairo, Egypt.

Drs. Abdelrahman and Salem are with the Faculty of Medicine at Benha University in Banha, Egypt.

出版信息

J Clin Aesthet Dermatol. 2023 Feb;16(2):55-59.

PMID:36909870
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10005806/
Abstract

BACKGROUND

Granzyme B (GZMB) gene is related to human immunity and is considered as one of the genes indulged in vitiligo.

OBJECTIVE

To evaluate the association between GZMB (R55Q) and (P94Q) gene polymorphisms with vitiligo development in a sample of vitiligo Egyptian patients.

METHODS

This study was a case-control study which included 100 non-segmental vitiligo patients as well as a control group consisted of 100 healthy, sex and age matched vitiligo free individuals. The polymorphism of GZMB gene at (R55Q) and (P94A) were analyzed by polymerase chain reaction.

RESULTS

P94Q and R55Q gene polymorphisms were significantly associated with higher VASI scores.

CONCLUSION

GZMB (Q55R) and P94A) gene polymorphisms are associated with the susceptibility to develop vitiligo in the Egyptian population and could help predicting more extensive forms of the disease.

摘要

背景

颗粒酶B（GZMB）基因与人类免疫相关，被认为是与白癜风相关的基因之一。

目的

在埃及白癜风患者样本中评估GZMB（R55Q）和（P94Q）基因多态性与白癜风发病之间的关联。

方法

本研究为病例对照研究，包括100例非节段性白癜风患者以及由100名年龄和性别匹配的无白癜风健康个体组成的对照组。通过聚合酶链反应分析GZMB基因在（R55Q）和（P94A）处的多态性。

结果

P94Q和R55Q基因多态性与较高的白癜风面积评分指数（VASI）显著相关。

结论

GZMB（Q55R）和P94A）基因多态性与埃及人群患白癜风的易感性相关，有助于预测病情更广泛的白癜风形式。