颗粒酶B基因多态性与重度非节段型白癜风相关。
Granzyme B Gene Polymorphisms Are Associated With Severe Non-segmental Vitiligo.
作者信息
El-Taweel Abd El-Aziz, Abdelrahman Amira, Hegazy Hebatallah, Salem Rehab
机构信息
Dr. El-Taweel is with Faculty of Medicine at 6th of October University in Cairo, Egypt.
Drs. Abdelrahman and Salem are with the Faculty of Medicine at Benha University in Banha, Egypt.
出版信息
J Clin Aesthet Dermatol. 2023 Feb;16(2):55-59.
BACKGROUND
Granzyme B (GZMB) gene is related to human immunity and is considered as one of the genes indulged in vitiligo.
OBJECTIVE
To evaluate the association between GZMB (R55Q) and (P94Q) gene polymorphisms with vitiligo development in a sample of vitiligo Egyptian patients.
METHODS
This study was a case-control study which included 100 non-segmental vitiligo patients as well as a control group consisted of 100 healthy, sex and age matched vitiligo free individuals. The polymorphism of GZMB gene at (R55Q) and (P94A) were analyzed by polymerase chain reaction.
RESULTS
P94Q and R55Q gene polymorphisms were significantly associated with higher VASI scores.
CONCLUSION
GZMB (Q55R) and P94A) gene polymorphisms are associated with the susceptibility to develop vitiligo in the Egyptian population and could help predicting more extensive forms of the disease.
背景
颗粒酶B（GZMB）基因与人类免疫相关，被认为是与白癜风相关的基因之一。
目的
在埃及白癜风患者样本中评估GZMB（R55Q）和（P94Q）基因多态性与白癜风发病之间的关联。
方法
本研究为病例对照研究，包括100例非节段性白癜风患者以及由100名年龄和性别匹配的无白癜风健康个体组成的对照组。通过聚合酶链反应分析GZMB基因在（R55Q）和（P94A）处的多态性。
结果
P94Q和R55Q基因多态性与较高的白癜风面积评分指数（VASI）显著相关。
结论
GZMB（Q55R）和P94A）基因多态性与埃及人群患白癜风的易感性相关，有助于预测病情更广泛的白癜风形式。
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