Yigit Ozgul, Sert Tuba Karakus, Ekinci Deniz, Kirankaya Aysegul, Kilinc Suna
Department of Pediatrics, Health Sciences University, Istanbul Bagcilar Training and Research Hospital, Istanbul, Turkiye.
Department of Radiology, Health Sciences University, Istanbul Bagcilar Training and Research Hospital, Istanbul, Turkiye.
North Clin Istanb. 2023 Feb 20;10(1):48-52. doi: 10.14744/nci.2021.78300. eCollection 2023.
Enlargement and cystic changes in ovaries of patients with long-standing overt hypothyroidism have been described in numerous case reports. However, there are limited data about the effect of subclinical hypothyroidism (SH) on ovarian volume. The aim of the study is to evaluate the relationship between serum thyroid stimulating hormone (TSH) level and ovarian volume in prepubertal girls with SH.
Patients who were aged between 6 and 10 years and diagnosed with SH and age-matched healthy euthyroid controls were enrolled in the study. All subjects were prepubertal.
Thirty-five children with SH (mean age; 7.6±1.0 years) and 50 euthyroid healthy girls (mean age; 7.7±1.2 years) were enrolled in the study. TSH and LH levels and both ovarian volumes were significantly higher in SH group than controls (p<0.05). In addition, TSH was positively correlated with ovarian volumes and LH in patients with SH (p<0.05).
The results of this study showed that ovarian volumes of prepubertal girls with SH were significantly greater than those with normal thyroid function. Although ovarian enlargement and cyst formation is well recognized in long-standing overt hypothyroidism, it has been shown for the 1 time in patients with SH.
众多病例报告描述了长期显性甲状腺功能减退患者卵巢增大及囊性改变。然而，关于亚临床甲状腺功能减退（SH）对卵巢体积的影响的数据有限。本研究的目的是评估青春期前患有SH的女孩血清促甲状腺激素（TSH）水平与卵巢体积之间的关系。
本研究纳入了年龄在6至10岁之间、诊断为SH的患者以及年龄匹配的健康甲状腺功能正常的对照者。所有受试者均处于青春期前。
35名患有SH的儿童（平均年龄；7.6±1.0岁）和50名甲状腺功能正常的健康女孩（平均年龄；7.7±1.2岁）纳入本研究。SH组的TSH和LH水平以及双侧卵巢体积均显著高于对照组（p<0.05）。此外，SH患者的TSH与卵巢体积和LH呈正相关（p<0.05）。
本研究结果表明，患有SH的青春期前女孩的卵巢体积显著大于甲状腺功能正常的女孩。虽然在长期显性甲状腺功能减退中卵巢增大和囊肿形成已得到充分认识，但在SH患者中这是首次被证实。
