Franco Juan V A, Tesolin Pablo, Jung Jae Hung
Institute of General Practice, Medical Faculty of the Heinrich-Heine-University Düsseldorf, Düsseldorf, Germany.
Family and Community Division, Hospital Italiano de Buenos Aires, Argentina.
Prostate Int. 2023 Mar;11(1):1-7. doi: 10.1016/j.prnil.2023.01.002. Epub 2023 Jan 10.
Lower urinary tract symptoms due to benign prostatic hyperplasia constitute a substantial burden, affecting the quality of life of those affected by this condition. While watchful waiting and medical management using a wide array of pharmaceuticals can be effective, surgery has been one of the most definite solutions for those highly affected by this condition. Transurethral resection of the prostate (TURP) is the gold standard surgical procedure, but other alternatives using laser (HoLEP and ThuLEP) and robotic water jets (Aquablation) are emerging treatments aimed at reducing postoperative morbidity. Minimally invasive procedures conducted in outpatient settings and under local anesthesia or sedation are increasingly being used, especially in those patients with high surgical risk due to comorbidities. These procedures include prostatic arterial embolization, water vapor thermal therapy (Rezum), prostatic urethral lift (Urolift), temporary implantable nitinol device (TIND/iTIND), and transurethral microwave thermotherapy (TUMT). The evidence supporting these treatments is growing, but some uncertainties remain as to what is the magnitude of their advantages and disadvantages compared to TURP. Innovations in the technologies involved in these new procedures may improve their profile for effectiveness and safety. Moreover, new devices are being investigated for marketing approval. Issues around costs and patients' preferences are also yet to be elucidated, thus their evolving role needs to be weighed against the aforementioned considerations.
良性前列腺增生导致的下尿路症状构成了一项沉重负担,影响着受此病症影响者的生活质量。虽然密切观察等待以及使用多种药物进行药物治疗可能有效,但手术一直是对此病症影响严重者最确切的解决办法之一。经尿道前列腺切除术(TURP)是金标准手术方式,但其他使用激光(HoLEP和ThuLEP)以及机器人水刀(Aquablation)的替代方法正在兴起,旨在降低术后发病率。在门诊环境中且在局部麻醉或镇静下进行的微创手术越来越多地被采用,尤其是在那些因合并症而手术风险高的患者中。这些手术包括前列腺动脉栓塞术、水蒸气热疗法(Rezum)、前列腺尿道悬吊术(Urolift)、临时可植入镍钛诺装置(TIND/iTIND)以及经尿道微波热疗(TUMT)。支持这些治疗方法的证据在不断增加,但与TURP相比,它们的优缺点程度如何仍存在一些不确定性。这些新手术所涉及技术的创新可能会改善其有效性和安全性方面的表现。此外,新设备正在接受调查以获得上市批准。成本和患者偏好方面的问题也有待阐明,因此需要将它们不断演变的作用与上述因素进行权衡。