小儿唐氏综合征中的生长激素释放激素-生长激素-胰岛素样生长因子-1轴：一项系统评价和小型荟萃分析。
GHRH-GH-IGF1 axis in pediatric Down syndrome: A systematic review and mini meta-analysis.
作者信息
Shaki David, Hershkovitz Eli, Tamam Shai, Bollotin Arkadi, David Odeya, Yalovitsky Guy, Loewenthal Neta, Carmon Lior, Walker Dganit, Haim Alon
机构信息
Pediatric Endocrinology Unit, Soroka University Medical Center, Beer Sheva, Israel.
Faculty of Health Sciences, Ben-Gurion University, Beer Sheva, Israel.
出版信息
Front Pediatr. 2023 Feb 22;11:1132296. doi: 10.3389/fped.2023.1132296. eCollection 2023.
OBJECTIVE
To analyze and determine the quality of functioning in different components of GHRH-GH-IGF1 axis in children with Down syndrome (DS).
DESIGN
Systematic review and mini meta-analysis of the literature.
METHODS
A search was performed in PubMed, Embase, Scopus, and PsycINFO through August 2022. Eligible studies included pediatric patients with DS who had undergone any laboratory evaluation of the GHRH-GH-IGF1 axis. Two reviewers independently screened articles for eligibility. Results of each type of test were weighed together in patients both with and without DS and were pooled using a random effects meta-analysis.
RESULTS
In total, 20 studies assessed the GHRH-GH-IGF1 axis function. A defect in three major components of GHRH-GH-IGF1 axis was found in a significant proportion of pediatric DS patients.
CONCLUSIONS
A significant portion of short-stature pathogenesis in children with DS is associated with impaired GHRH-GH-IGF1 axis function.
目的
分析并确定唐氏综合征（DS）患儿生长激素释放激素-生长激素-胰岛素样生长因子1（GHRH-GH-IGF1）轴不同组成部分的功能质量。
设计
对文献进行系统综述和小型荟萃分析。
方法
截至2022年8月，在PubMed、Embase、Scopus和PsycINFO数据库中进行检索。符合条件的研究包括对GHRH-GH-IGF1轴进行过任何实验室评估的DS儿科患者。两名评审员独立筛选文章的合格性。在患有和未患有DS的患者中，将每种测试的结果进行综合权衡，并采用随机效应荟萃分析进行汇总。
结果
共有20项研究评估了GHRH-GH-IGF1轴功能。在相当一部分DS儿科患者中发现GHRH-GH-IGF1轴的三个主要组成部分存在缺陷。
结论
DS患儿身材矮小发病机制的很大一部分与GHRH-GH-IGF1轴功能受损有关。
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