锌离子在严重急性呼吸综合征冠状病毒2（SARS-CoV-2）orf7a蛋白与BST2/栓系蛋白相互作用中的作用

The role of Zn ions in the interaction between SARS-CoV-2 orf7a protein and BST2/tetherin.

作者信息

Botticelli S, Chiaraluce R, Consalvi V, La Penna G, Pasquo A, Petrosino M, Proux O, Rossi G C, Stellato F, Morante S

机构信息

Università di Roma "Tor Vergata" and INFN, Sezione di Roma 2 - Via della Ricerca Scientifica 1, 00133 Rome, Italy.

Dipartimento di Biochimica, Sapienza Universitá di Roma, Piazzale Aldo Moro 5, 00185 Rome, Italy.

出版信息

Eur Phys J Plus. 2023;138(3):216. doi: 10.1140/epjp/s13360-023-03731-w. Epub 2023 Mar 8.

In this paper, we provide evidence that Zn ions play a role in the SARS-CoV-2 virus strategy to escape the immune response mediated by the BST2-tetherin host protein. This conclusion is based on sequence analysis and molecular dynamics simulations as well as X-ray absorption experiments [1].