辅助放疗治疗口腔鳞状细胞癌患者中预防性与反应性喂养方法的比较：倾向评分匹配对分析。
Prophylactic versus reactive feeding approach in patients undergoing adjuvant radiation therapy for oral cavity squamous cell carcinoma: A propensity score matched-pair analysis.
机构信息
Department of Radiation Oncology, Tata Memorial Centre, Homi Bhabha National Institute, Mumbai, Maharashtra, India.
Clinical Research Secretariat, Tata Memorial Centre, Homi Bhabha National Institute, Mumbai, Maharashtra, India.
出版信息
Head Neck. 2023 May;45(5):1226-1236. doi: 10.1002/hed.27336. Epub 2023 Mar 13.
BACKGROUND
To assess the efficacy of prophylactic versus reactive feeding strategy in oral cavity squamous cell carcinoma (OCSCC) patients receiving adjuvant radiation therapy (RT).
METHODS
This was a post hoc analysis of patients of OCSCC enrolled in a randomized trial comparing three adjuvant strategies. In this trial, till 2010, a prophylactic feeding approach was followed for all patients. Since January 2011, a reactive feeding approach was followed.
RESULTS
Two hundred and sixty-eight in each cohort (total n = 526) were eligible for analysis after propensity score matching. At 6 weeks post-RT completion, the median weight loss in the prophylactic versus reactive cohort was 5 versus 3 kg, p = 0.002. At all other time points until 1 year, the median weight loss was lesser in reactive than in the prophylactic cohort.
CONCLUSIONS
A reactive feeding tube approach should be preferred for OCSCC receiving adjuvant RT.
背景
评估口腔鳞状细胞癌（OCSCC）患者接受辅助放疗（RT）时预防性与反应性喂养策略的疗效。
方法
这是一项针对 OCSCC 患者的回顾性分析，这些患者入组了一项比较三种辅助策略的随机试验。在这项试验中，直到 2010 年，所有患者都采用预防性喂养方法。自 2011 年 1 月以来，采用了反应性喂养方法。
结果
经过倾向评分匹配后，两个队列各有 268 例（总 n=526）符合分析条件。在 RT 完成后 6 周时，预防性与反应性队列的中位体重减轻分别为 5 公斤和 3 公斤，p=0.002。在 1 年之前的所有其他时间点，反应性队列的中位体重减轻均小于预防性队列。
结论
对于接受辅助 RT 的 OCSCC 患者，应首选反应性喂养管方法。
Zotero 插件