Clin Lab. 2023 Mar 1;69(3). doi: 10.7754/Clin.Lab.2022.210903.
This study aims to investigate the serum fat-soluble vitamins A, D, and E levels of children in Zhejiang Province, and to provide a reference range of fat-soluble vitamins for children in Zhejiang Province.
Between May 2019 and December 2019, 871 children who sent peripheral blood samples to Hangzhou Biozon Medical Institute Co., Ltd. for fat-soluble vitamin A, D, and E analysis were selected, including 432 boys and 439 girls. After the peripheral blood was collected, the serum A, D, and E levels were measured, and the differences in age, gender, season, and region were compared.
With age, the level of vitamin A gradually increased (p < 0.01), and vitamin D2, D3, and total vitamin D all increased first and then decreased. Vitamin A (131.79 ± 47.05 ng/mL vs. 121.96 ± 41.01 ng/mL) and E (5.87 ± 2.23 μg/mL vs. 5.56 ± 2.13 μg/mL) levels of girls were higher than boys (p < 0.01), and vitamin D3 (15.25 ± 6.16 ng/mL vs.15.17 ± 7.26 ng/mL) and total vitamin D (18.09 ± 7.01 ng/mL vs. 17.03 ± 8.79 ng/mL) levels of boys were higher than girls (p < 0.01). From the perspective of regional distribution, the levels of vitamin A, D2, and E in Ningbo were higher than those in Hangzhou and other regions. The seasonal distribution of vitamin A and E levels were highest in summer, while vitamin D3 and D levels were highest in fall. The average vitamin concentrations were as follows: vitamin A was (126.81 ± 44.42) ng/mL; vitamin D2 was (1.84 ± 3.16) ng/mL, vitamin D3 was (15.71 ± 6.75) ng/mL, total vitamin D was (17.55 ± 7.91) ng/mL, and vitamin E was (5.72 ± 2.19) μg/mL. The reference value ranges of vitamin A, D2, D3, D, and E were (52.44 - 222.27) ng/mL, (0.01 - 11.66) ng/mL, (4.92 - 30.96) ng/mL, (4.92 - 30.96) ng/mL, and (2.66 - 10.92) μg/mL, respectively.
The childrens' fat soluble vitamin levels in Zhejiang province show significant differences in age, gender, season, and regional distribution. Corresponding reference standards should be formulated as soon as possible, and vitamin supplements should be targeted and reasonable to ensure the healthy development of children.
本研究旨在调查浙江省儿童血清脂溶性维生素 A、D、E 水平，为浙江省儿童提供脂溶性维生素的参考范围。
2019 年 5 月至 2019 年 12 月，选择 871 名因外周血样本送至杭州比逊医学检验有限公司进行脂溶性维生素 A、D、E 分析的儿童，包括 432 名男孩和 439 名女孩。采集外周血后，检测血清 A、D、E 水平，并比较年龄、性别、季节和地区的差异。
随年龄增长，维生素 A 水平逐渐升高（p＜0.01），维生素 D2、D3 和总维生素 D 均先升高后降低。女孩的维生素 A（131.79±47.05ng/mL 比 121.96±41.01ng/mL）和 E（5.87±2.23μg/mL 比 5.56±2.13μg/mL）水平高于男孩（p＜0.01），而男孩的维生素 D3（15.25±6.16ng/mL 比 15.17±7.26ng/mL）和总维生素 D（18.09±7.01ng/mL 比 17.03±8.79ng/mL）水平高于女孩（p＜0.01）。从地域分布来看，宁波地区维生素 A、D2 和 E 的水平高于杭州等其他地区。维生素 A 和 E 水平的季节性分布在夏季最高，而维生素 D3 和 D 水平在秋季最高。平均维生素浓度如下：维生素 A（126.81±44.42）ng/mL；维生素 D2（1.84±3.16）ng/mL，维生素 D3（15.71±6.75）ng/mL，总维生素 D（17.55±7.91）ng/mL，维生素 E（5.72±2.19）μg/mL。维生素 A、D2、D3、D 和 E 的参考值范围分别为（52.44-222.27）ng/mL、（0.01-11.66）ng/mL、（4.92-30.96）ng/mL、（4.92-30.96）ng/mL 和（2.66-10.92）μg/mL。
浙江省儿童脂溶性维生素水平在年龄、性别、季节和地域分布上存在显著差异。应尽快制定相应的参考标准，并针对性、合理地补充维生素，以保证儿童的健康成长。
