Clin Lab. 2023 Mar 1;69(3). doi: 10.7754/Clin.Lab.2022.220726.
As a rare heterogeneous kind of acute leukemia, mixed-phenotype acute leukemia (MPAL) co-expresses more than one cell lineage and could contain bilineal, biphenotypic, or a combination. MPAL is classified as T/myeloid, B/myeloid, B/T-lymphoid, and trilineage B/T/myeloid.
Here, we report a rare case of T/Myeloid bilineage mixed-phenotype acute leukemia with basophilia.
The puzzling morphological features are due to two distinct kinds of blasts have put hematologists into a dilemma. The diagnosis of T/myeloid MPAL with basophilia was established based on integrated diagnostics.
To date, no case of a patient diagnosed with T/Myeloid bilineage MPAL with basophilia has been reported. The case focuses on the importance of an integrated diagnostic work-up, with a challenging morphological presentation and crucial role for flow cytometry.
混合表型急性白血病（MPAL）是一种罕见的异质性急性白血病，同时表达一种以上细胞谱系，可包含双系、双表型或两者的组合。MPAL 分为 T/髓系、B/髓系、B/T 淋巴系和三系 B/T/髓系。
我们在此报告一例伴嗜碱性粒细胞的罕见 T/髓系双系混合表型急性白血病病例。
由于两种不同类型的原始细胞导致形态学特征令人困惑，使血液学家陷入困境。基于综合诊断确立了伴嗜碱性粒细胞的 T/髓系 MPAL 的诊断。
迄今为止，尚未报道过伴嗜碱性粒细胞的 T/髓系双系 MPAL 患者的病例。该病例重点强调了综合诊断检查的重要性，其具有挑战性的形态学表现和流式细胞术的关键作用。
