Clin Lab. 2023 Mar 1;69(3). doi: 10.7754/Clin.Lab.2022.220515.
This observational study was designed to evaluate prothrombin time and activity (PT, PT%), prothrombin time international normalized ratio (INR), activated partial thromboplastin time (APTT), coagulation enzyme time (TT), fibrinogen content (FIB), D-dimer (D-dimer), and platelet count (Plt) in patients with hemorrhoids (HE, n = 207), hemorrhoids with bleeding (HB, n = 59), and incarcerated hemorrhoids (IH, n = 10) and the utility of these parameters in the differential diagnosis of hemorrhoids with thrombosis (HT, n = 30).
Patients were grouped according to the relevant clinical diagnosis and classification standards. Blood coagulation-related tests, platelet counts, and relevant laboratory indicators (PT%, PT, APTT, TT, INR, FIB, D-dimer, and Plt) were carried out with samples obtained from patients with hemorrhoids.
In the ROC curve analysis, D-dimer could better distinguish HE from HB (AUC = 0.587, p = 0.042). D-dimer (AUC = 0.643, p = 0.011), INR (AUC = 0.630, p = 0.022), and TT (AUC = 0.617, p = 0.038) could distinguish HT from HE, although no significant difference was observed between the ROC curves.
D-dimer is useful in distinguishing HE from HB. Moreover, D-dimer, INR, and TT are useful in distinguishing HE from HT. Our findings provide a theoretical basis for future research in this area.
本观察性研究旨在评估痔疮（HE，n=207）、痔疮伴出血（HB，n=59）和嵌顿痔（IH，n=10）患者的凝血酶原时间和活度（PT、PT%）、凝血酶原时间国际标准化比值（INR）、活化部分凝血活酶时间（APTT）、凝血酶时间（TT）、纤维蛋白原含量（FIB）、D-二聚体（D-dimer）和血小板计数（Plt），并探讨这些参数在鉴别血栓性痔疮（HT，n=30）中的作用。
根据相关临床诊断和分类标准对患者进行分组。采用患者样本进行凝血相关检查、血小板计数及相关实验室指标（PT%、PT、APTT、TT、INR、FIB、D-dimer 和 Plt）检测。
在 ROC 曲线分析中，D-二聚体能够更好地区分 HE 与 HB（AUC=0.587，p=0.042）。D-二聚体（AUC=0.643，p=0.011）、INR（AUC=0.630，p=0.022）和 TT（AUC=0.617，p=0.038）可区分 HT 与 HE，但 ROC 曲线之间无显著差异。
D-二聚体有助于区分 HE 与 HB，且 D-二聚体、INR 和 TT 有助于区分 HE 与 HT。本研究结果为该领域的进一步研究提供了理论依据。
