Clin Lab. 2023 Mar 1;69(3). doi: 10.7754/Clin.Lab.2022.220617.
Multidrug-resistant Gram-negative bacteria particularly Klebsiella, Pseudomonas and Acinetobacter species are recognized as a major health concern worldwide. As a result, the World Health Organization listed these bacteria in the critical priority pathogens group. This study aimed to assess the prevalence of carbapenem and multidrug-resistant Klebsiella, Pseudomonas, and Acinetobacter species at the University of Gondar Comprehensive Specialized Hospital.
A five-year hospital based retrospective study was conducted from July to September 2021. Socio-demographic and laboratory data were collected from medical records in microbiology laboratory. The quality of the extracted data was assured through cross checking. The data were entered through Epi-data version 4.4.3.1, exported and analyzed using SPSS version 20. The variables were analyzed and presented through tables and graphics.
In this study, the frequencies of male participants and neonates under the age of one week were 585 (62.8%) and 210 (22.6%), respectively. Approximately half (436; 46.8%) of the bacterial isolates were recovered from blood specimen. A total of 931 isolates were recorded, where 576 (61.9%) of these isolates were multidrug-resistant. More than two-third of Klebsiella ozaenae (87; 68.5%) and Klebsiella pneumoniae (398; 63.3%) were multidrug-resistant. Of the total bacterial isolates, 24 (13.1%) and 82 (22.9%) were resistant to imipenem and meropenem, respectively.
The proportion of multidrug and carbapenem resistance in Klebsiella, Pseudomonas and Acinetobacter species were high. Therefore, urgent intervention including prevention of the spread of antimicrobial resistant strains and infection prevention practices is required. Treatment should also be guided with antimicrobial susceptibility testing.
多药耐药革兰氏阴性菌，尤其是肺炎克雷伯菌、铜绿假单胞菌和鲍曼不动杆菌，被认为是全球主要的健康关注点。因此，世界卫生组织将这些细菌列入了关键优先病原体组。本研究旨在评估在贡德尔大学综合专科医院，碳青霉烯类和多药耐药肺炎克雷伯菌、铜绿假单胞菌和鲍曼不动杆菌的流行率。
这是一项为期五年的基于医院的回顾性研究，于 2021 年 7 月至 9 月进行。从微生物实验室的病历中收集了社会人口统计学和实验室数据。通过交叉核对确保提取数据的质量。数据通过 Epi-data 版本 4.4.3.1 输入，使用 SPSS 版本 20 进行导出和分析。通过表格和图形分析和呈现变量。
在这项研究中，男性参与者和年龄不满一周的新生儿的频率分别为 585（62.8%）和 210（22.6%）。大约一半（436；46.8%）的细菌分离株是从血液标本中分离出来的。共记录了 931 株分离株，其中 576 株（61.9%）为多药耐药菌。恶臭克雷伯菌（87 株；68.5%）和肺炎克雷伯菌（398 株；63.3%）中超过三分之二为多药耐药菌。在总细菌分离株中，24 株（13.1%）和 82 株（22.9%）对亚胺培南和美罗培南分别耐药。
肺炎克雷伯菌、铜绿假单胞菌和鲍曼不动杆菌的多药和碳青霉烯耐药比例较高。因此，需要紧急干预，包括防止耐药菌株的传播和感染预防措施。治疗还应根据抗菌药物敏感性试验进行指导。
