Xu Yiran, Wang Shengchun, Liu Zhao, Guo Mian, Lei Aiwen
College of Chemistry and Molecular Sciences, The Institute for Advanced Studies (IAS), Wuhan University, Wuhan 430072, P. R. China.
Chem Commun (Camb). 2023 Mar 23;59(25):3707-3710. doi: 10.1039/d2cc05934g.
Radical defluorinative functionalization of α-trifluoromethyl styrenes represents an effective way toward -difluoroalkenes. There are general interests in developing novel synthetic protocols for defluorinative functionalization with various types of radicals. However, reports on the preparation of -difluoro allylsulfones an -centered radical pathway are limited. Herein, we developed a photo/nickel dual-catalyzed defluorinative sulfonylation that rapidly and reliably synthesizes -difluoro allylsulfones. The merit of this protocol is exhibited by its mild conditions and wide scope, thus providing a novel strategy for the sulfonyl radical participating in radical defluorinative coupling.
α-三氟甲基苯乙烯的自由基脱氟官能团化是合成二氟烯烃的有效方法。开发各种类型自由基的脱氟官能团化新合成方法具有广泛的研究兴趣。然而，通过以α-中心自由基途径制备二氟烯丙基砜的报道有限。在此，我们开发了一种光/镍双催化的脱氟磺酰化反应，可快速可靠地合成二氟烯丙基砜。该方法具有条件温和、适用范围广的优点，为磺酰基自由基参与自由基脱氟偶联反应提供了一种新策略。
