The e1a3 fusion transcript in Philadelphia chromosome-positive acute lymphoblastic leukaemia: a case report.

The Philadelphia (Ph) chromosome results from the formation of breakpoint cluster region ()-Abelson 1 () fusion gene (). The most common type of adult acute lymphoblastic leukaemia (ALL) is Ph chromosome-positive (Ph+); Ph+ ALL has an incidence of 25%∼30%. Several types of fusion transcripts have been reported, including e1a2, e13a2 and e14a2. In addition, some rare transcripts, such as e1a3, have been reported in chronic myeloid leukaemia. However, until now, the presence of e1a3 fusion transcripts has only been reported in a few cases of ALL. In this study, a rare e1a3 fusion transcript was found in a patient diagnosed with Ph+ ALL. However, the patient also suffered from severe agranulocytosis with pulmonary infection and died after being transferred to the intensive care unit before the significance of the presence of e1a3 fusion transcript could be determined. In conclusion, e1a3 fusion transcripts related to Ph+ ALL cases need to be better identified, and appropriate treatment strategies must be designed for such cases.