神经递质系统在终身早泄男性中的可能病理生理作用：一项范围综述方案

Possible Pathophysiological Roles of Neurotransmitter Systems in Men With Lifelong Premature Ejaculation: Protocol for a Scoping Review.

作者信息

Van Raaij Joost Johan, Janssen Paddy Koen Camiel

机构信息

Department of Clinical Pharmacy and Toxicology, VieCuri Medical Centre, Venlo, Netherlands.

Department of Clinical Pharmacy and Toxicology, Maastricht University Medical Centre, Maastricht, Netherlands.

出版信息

JMIR Res Protoc. 2023 Mar 13;12:e41301. doi: 10.2196/41301.

DOI:10.2196/41301

PMID:36912871

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10131874/

Abstract

BACKGROUND

Lifelong premature ejaculation (LPE) is a rare sexual condition believed to be caused by genetic neurobiological disorders. In the field of LPE, 2 main types of research have been conducted: direct genetic research and pharmacotherapeutic interference of neurotransmitter systems that can relieve the symptoms of LPE in male patients.

OBJECTIVE

We aim to provide an overview of studies on neurotransmitter systems as the pathophysiological cause of LPE by investigating direct genetic research or pharmacotherapeutic interference that relieves the main symptom of LPE in male patients.

METHODS

This scoping review will use the PRISMA-ScR tool (Preferred Reporting Items for Systematic Reviews and Meta-Analyses extension for Scoping Reviews). In addition, this study will use a peer-reviewed search strategy. Systematic searches will be conducted using 5 scientific databases (Cochrane Database of Systematic Reviews, PubMed or MEDLINE, Cumulative Index to Nursing and Allied Health Literature [CINAHL], EMBASE, and Epistemonikos). Additionally, pragmatic searches for relevant information in gray literature databases will be performed. Two reviewers will independently include relevant studies in a 2-stage selection strategy. Finally, data will be extracted from the studies and charted to summarize relevant study characteristics and key findings.

RESULTS

As of July 2022, we completed the preliminary searches according to the PRESS 2015 guidelines and started to determine the final search terms that we will use in all selected 5 scientific databases.

CONCLUSIONS

This scoping review protocol is the first to focus on neurotransmitter pathways in LPE by combining the results from the genetic and pharmacotherapy studies. The results could help identify potential research gaps or target candidate proteins and neurotransmitter pathways in LPE for further genetic research.

TRIAL REGISTRATION

Open Science Framework 10.17605/OSF.IO/JUQSD; https://osf.io/juqsd.

INTERNATIONAL REGISTERED REPORT IDENTIFIER (IRRID): PRR1-10.2196/41301.

摘要

背景

终身早泄（LPE）是一种罕见的性功能障碍，被认为是由遗传性神经生物学紊乱引起的。在LPE领域，主要进行了两种类型的研究：直接基因研究和对神经递质系统的药物治疗干预，后者可缓解男性患者的LPE症状。

目的

我们旨在通过研究直接基因研究或缓解男性患者LPE主要症状的药物治疗干预，概述将神经递质系统作为LPE病理生理原因的研究。

方法

本范围综述将使用PRISMA-ScR工具（系统评价和Meta分析扩展版的首选报告项目）。此外，本研究将采用同行评审的搜索策略。将使用5个科学数据库（Cochrane系统评价数据库、PubMed或MEDLINE、护理及相关健康文献累积索引 [CINAHL]、EMBASE和Epistemonikos）进行系统检索。此外，还将在灰色文献数据库中进行实用的相关信息搜索。两名评审员将在两阶段选择策略中独立纳入相关研究。最后，将从研究中提取数据并制成图表，以总结相关研究特征和主要发现。