Department of Obstetrics and Gynecology, Hasanuddin University, Makassar, Indonesia.
Department of Obstetrics and Gynecology, Hasanuddin University, Makassar, Indonesia -
Minerva Obstet Gynecol. 2024 Oct;76(5):410-415. doi: 10.23736/S2724-606X.23.05279-X. Epub 2023 Mar 13.
Clinical stages, histologic type, degree of cell differentiation, myometrial invasion, and lymph-vascular space invasion (LVSI) have been identified as clinicopathological factors that are predictive for endometrial cancer, however, further prognostic indicators are still required to account for the heterogeneity of this cancer. Adhesion molecule CD44, affects the invasion, metastasis, and prognosis of many forms of cancer. The purpose of this study is to examine the expression of CD44 in endometrial cancer and its correlation with established prognostic variables.
A cross-sectional study was conducted on 64 samples of endometrial cancer from Wahidin Sudirohusodo Hospital and Hasanuddin University Hospital. Immunohistochemical analysis was used to detect CD44 expression using mouse anti-human CD44 monoclonal antibody. Differences in Histoscore were studied to determine the association between CD44 expression and clinicopathological factors of endometrial cancer.
Of the overall sample, 46 samples were in the early stage, whereas 18 samples were in the advanced stage. High expression of CD44 was associated with advanced stage compare than early stage (P=0.010), poor differentiation compare than well-moderate differentiation (P=0.001), myometrial invasion ≥50% compare than myometrial invasion <50% (P=0.004), and positive LVSI compare than negative LVSI (P=0.043) in endometrial cancer, but not associated with histological type of endometrial cancer (P=0.178).
High expression of CD44 may be considered as a poor prognostic marker and predictive marker for targeted therapy in endometrial cancer.
临床分期、组织学类型、细胞分化程度、肌层浸润和淋巴血管间隙浸润（LVSI）已被确定为预测子宫内膜癌的临床病理因素，但仍需要进一步的预后指标来解释这种癌症的异质性。黏附分子 CD44 影响多种癌症的侵袭、转移和预后。本研究旨在研究 CD44 在子宫内膜癌中的表达及其与既定预后变量的相关性。
对 Wahidin Sudirohusodo 医院和哈桑努丁大学医院的 64 例子宫内膜癌样本进行了横断面研究。使用小鼠抗人 CD44 单克隆抗体进行免疫组织化学分析以检测 CD44 表达。研究了 Histoscore 的差异，以确定 CD44 表达与子宫内膜癌临床病理因素之间的关联。
在整个样本中，46 例为早期，18 例为晚期。与早期相比，晚期子宫内膜癌中 CD44 高表达（P=0.010）、分化差与中-高分化相比（P=0.001）、肌层浸润≥50%与肌层浸润<50%相比（P=0.004）、LVSI 阳性与 LVSI 阴性相比（P=0.043），但与子宫内膜癌的组织学类型无关（P=0.178）。
CD44 高表达可能被视为子宫内膜癌的不良预后标志物和靶向治疗的预测标志物。
