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[无症状性心房颤动:筛查与治疗]

[Asymptomatic atrial fibrillation : Screening and therapy].

作者信息

Gunawardene Melanie, Hartmann Jens, Willems Stephan

机构信息

Klinik für Kardiologie und internistische Intensivmedizin, Asklepios Klinik St. Georg, Lohmühlenstr. 5, 20099, Hamburg, Deutschland.

出版信息

Herzschrittmacherther Elektrophysiol. 2023 Jun;34(2):122-130. doi: 10.1007/s00399-023-00933-8. Epub 2023 Mar 13.

DOI:10.1007/s00399-023-00933-8
PMID:36912974
Abstract

Atrial fibrillation (AF) is the most common cardiac arrhythmia affecting millions of people worldwide and poses a significant burden to the health care system. AF screening of the general population or of a specific higher-risk population could not only lead to earlier detection of AF but also to a prompt initiation of an adequate therapy to prevent complications such as stroke or death and consecutively to a potential reduction of health care costs, especially in asymptomatic AF patients. To conduct screening programs, accessible new technology devices such as "wearables", smartwatches, and implantable event recorders provide an innovative solution. However, as data regarding screening are inconclusive, routine AF screening of the population is currently not recommended by the European Society of Cardiology. Recently published studies have indicated that anticoagulation and early rhythm control of asymptomatic AF could avoid occurrence of clinical endpoints. This article reports on the scientific results of the current literature as well as gaps of evidence and discusses possible treatment options of asymptomatic AF.

摘要

心房颤动(AF)是影响全球数百万人的最常见心律失常,给医疗保健系统带来了沉重负担。对普通人群或特定高风险人群进行AF筛查,不仅可以更早地检测出AF,还能促使及时启动适当治疗,以预防中风或死亡等并发症,并进而有可能降低医疗保健成本,尤其是对于无症状AF患者。为开展筛查项目,诸如“可穿戴设备”、智能手表和植入式事件记录仪等易于获取的新技术设备提供了创新解决方案。然而,由于有关筛查的数据尚无定论,欧洲心脏病学会目前不建议对人群进行常规AF筛查。最近发表的研究表明,无症状AF的抗凝治疗和早期节律控制可避免临床终点事件的发生。本文报告了当前文献的科学结果以及证据空白,并讨论了无症状AF可能的治疗选择。

相似文献

1
[Asymptomatic atrial fibrillation : Screening and therapy].[无症状性心房颤动:筛查与治疗]
Herzschrittmacherther Elektrophysiol. 2023 Jun;34(2):122-130. doi: 10.1007/s00399-023-00933-8. Epub 2023 Mar 13.
2
Antithrombotic therapy in atrial fibrillation associated with valvular heart disease: a joint consensus document from the European Heart Rhythm Association (EHRA) and European Society of Cardiology Working Group on Thrombosis, endorsed by the ESC Working Group on Valvular Heart Disease, Cardiac Arrhythmia Society of Southern Africa (CASSA), Heart Rhythm Society (HRS), Asia Pacific Heart Rhythm Society (APHRS), South African Heart (SA Heart) Association and Sociedad Latinoamericana de Estimulación Cardíaca y Electrofisiología (SOLEACE).心房颤动合并心脏瓣膜病的抗栓治疗:欧洲心律协会(EHRA)和欧洲心脏病学会血栓工作组的联合共识文件,得到 ESC 心脏瓣膜病工作组、南非心脏协会(SA Heart)、心律学会(HRS)、亚太心律学会(APHRS)、南非心脏协会(SA Heart)和拉丁美洲心脏刺激和电生理学会(SOLEACE)的认可。
Europace. 2017 Nov 1;19(11):1757-1758. doi: 10.1093/europace/eux240.
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2016 Guidelines of the Taiwan Heart Rhythm Society and the Taiwan Society of Cardiology for the management of atrial fibrillation.台湾心律学会与台湾心脏病学会2016年心房颤动管理指南。
J Formos Med Assoc. 2016 Nov;115(11):893-952. doi: 10.1016/j.jfma.2016.10.005. Epub 2016 Nov 24.
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Clinical classification and the subclinical atrial fibrillation challenge: a position paper of the European Cardiac Arrhythmia Society.临床分类与亚临床房颤挑战:欧洲心律失常学会立场文件。
J Interv Card Electrophysiol. 2020 Dec;59(3):495-507. doi: 10.1007/s10840-020-00859-y. Epub 2020 Oct 13.
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[2020 ESC guidelines on atrial fibrillation : Summary of the most relevant recommendations and innovations].[2020年欧洲心脏病学会心房颤动指南:最相关建议及创新内容总结]
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Atrial fibrillation burden and atrial fibrillation type: Clinical significance and impact on the risk of stroke and decision making for long-term anticoagulation.房颤负荷与房颤类型:临床意义及对卒中风险和长期抗凝决策的影响
Vascul Pharmacol. 2016 Aug;83:26-35. doi: 10.1016/j.vph.2016.03.006. Epub 2016 May 16.
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Improving outcomes in patients with atrial fibrillation: rationale and design of the Early treatment of Atrial fibrillation for Stroke prevention Trial.改善心房颤动患者的结局:预防卒中的心房颤动早期治疗试验的原理和设计。
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Catheter ablation in combination with left atrial appendage closure for atrial fibrillation.导管消融联合左心耳封堵治疗心房颤动
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[Screening and diagnosis of atrial fibrillation].[心房颤动的筛查与诊断]
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Management of atrial fibrillation: two decades of progress - a scientific statement from the European Cardiac Arrhythmia Society.心房颤动的管理:二十年的进展——欧洲心律失常学会的科学声明。
J Interv Card Electrophysiol. 2022 Oct;65(1):287-326. doi: 10.1007/s10840-022-01195-z. Epub 2022 Apr 13.

引用本文的文献

1
[Characterization of atrial fibrillation burden using wearables].[使用可穿戴设备对房颤负荷进行特征分析]
Herzschrittmacherther Elektrophysiol. 2024 Jun;35(2):111-117. doi: 10.1007/s00399-024-00995-2. Epub 2024 Feb 9.

本文引用的文献

1
Prognostic impact of catheter ablation in patients with asymptomatic atrial fibrillation.导管消融对无症状心房颤动患者的预后影响。
PLoS One. 2022 Dec 15;17(12):e0279178. doi: 10.1371/journal.pone.0279178. eCollection 2022.
2
Progression of Atrial Fibrillation after Cryoablation or Drug Therapy.冷冻消融或药物治疗后心房颤动的进展。
N Engl J Med. 2023 Jan 12;388(2):105-116. doi: 10.1056/NEJMoa2212540. Epub 2022 Nov 7.
3
Smartphone-based screening for atrial fibrillation: a pragmatic randomized clinical trial.基于智能手机的心房颤动筛查:一项实用随机临床试验。
Nat Med. 2022 Sep;28(9):1823-1830. doi: 10.1038/s41591-022-01979-w. Epub 2022 Aug 28.
4
Atrial fibrillation progression and the importance of early treatment for improving clinical outcomes.心房颤动的进展及早期治疗对改善临床结局的重要性。
Europace. 2022 Jun 6;24(Suppl 2):ii22-ii28. doi: 10.1093/europace/euab257.
5
Implantable loop recorder detection of atrial fibrillation to prevent stroke (The LOOP Study): a randomised controlled trial.植入式循环记录仪检测心房颤动以预防卒中(LOOP研究):一项随机对照试验
Lancet. 2021 Oct 23;398(10310):1507-1516. doi: 10.1016/S0140-6736(21)01698-6. Epub 2021 Aug 29.
6
Systematic, early rhythm control strategy for atrial fibrillation in patients with or without symptoms: the EAST-AFNET 4 trial.有症状或无症状的房颤患者的系统、早期节律控制策略:EAST-AFNET 4 试验。
Eur Heart J. 2022 Mar 21;43(12):1219-1230. doi: 10.1093/eurheartj/ehab593.
7
2021 Guideline for the Prevention of Stroke in Patients With Stroke and Transient Ischemic Attack: A Guideline From the American Heart Association/American Stroke Association.《2021年卒中与短暂性脑缺血发作患者卒中预防指南:美国心脏协会/美国卒中协会指南》
Stroke. 2021 Jul;52(7):e364-e467. doi: 10.1161/STR.0000000000000375. Epub 2021 May 24.
8
Clinical Outcomes in Asymptomatic and Symptomatic Atrial Fibrillation Presentations in GARFIELD-AF: Implications for AF Screening.GARFIELD-AF 研究中无症状与有症状房颤患者的临床结局:对房颤筛查的启示。
Am J Med. 2021 Jul;134(7):893-901.e11. doi: 10.1016/j.amjmed.2021.01.017. Epub 2021 Feb 16.
9
Catheter ablation or medical therapy to delay progression of atrial fibrillation: the randomized controlled atrial fibrillation progression trial (ATTEST).导管消融或药物治疗延缓心房颤动进展:随机对照心房颤动进展试验(ATTEST)。
Europace. 2021 Mar 8;23(3):362-369. doi: 10.1093/europace/euaa298.
10
Cryoablation or Drug Therapy for Initial Treatment of Atrial Fibrillation.冷冻消融或药物治疗用于初始治疗心房颤动。
N Engl J Med. 2021 Jan 28;384(4):305-315. doi: 10.1056/NEJMoa2029980. Epub 2020 Nov 16.