Toyota Central Research and Development Laboratories Incorporated, Nagakute, 480-1192, Japan.
Shiga University of Medical Science, Otsu, 520-2192, Japan.
Biotechnol Lett. 2023 Apr;45(4):551-561. doi: 10.1007/s10529-023-03361-3. Epub 2023 Mar 13.
We examined the inactivation of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) by a nitrogen-doped titanium dioxide (N-TiO) visible-light photocatalyst that was activated via light irradiation in the natural environment and was safe for human use as a coating material.
The photocatalytic activity of glass slides coated with three types of N-TiO without metal or loaded with copper or silver and copper was investigated by measuring acetaldehyde degradation. The titer levels of infectious SARS-CoV-2 were measured using cell culture after exposing photocatalytically active coated glass slides to visible light for up to 60 min.
N-TiO photoirradiation inactivated the SARS-CoV-2 Wuhan strain and this effect was enhanced by copper loading and further by the addition of silver. Hence, visible-light irradiation using silver and copper-loaded N-TiO inactivated the Delta, Omicron, and Wuhan strains.
N-TiO could be used to inactivate SARS-CoV-2 variants, including emerging variants, in the environment.
我们研究了氮掺杂二氧化钛（N-TiO）可见光光催化剂对严重急性呼吸综合征冠状病毒 2（SARS-CoV-2）的灭活作用，该催化剂在自然环境中通过光照激活，并且作为涂层材料对人体使用是安全的。
通过测量乙醛降解来研究涂覆有三种类型的 N-TiO 的载玻片的光催化活性，这些 N-TiO 既没有金属负载，也没有负载铜或银以及铜。将光催化活性涂覆的载玻片暴露于可见光下长达 60 分钟后，通过细胞培养来测量传染性 SARS-CoV-2 的滴度水平。
N-TiO 光照射使武汉株 SARS-CoV-2 失活，铜负载进一步增强了这种作用，而添加银则进一步增强了这种作用。因此，使用载银和铜的 N-TiO 进行可见光照射可以使 Delta、Omicron 和武汉株失活。
N-TiO 可用于环境中灭活 SARS-CoV-2 变体，包括新兴变体。
