Department of Psychology, Finis Terrae University, Santiago, Chile.
PLoS One. 2023 Mar 13;18(3):e0283011. doi: 10.1371/journal.pone.0283011. eCollection 2023.
Gender Incongruence refers to the discordance between biological sex and gender identity. Although it is possible to find literature reviews about the etiology of Gender Incongruence, almost all of these correspond to non-systematic narrative reviews, so they do not make explicit the methodology used in the collection and analysis of sources, even less its levels of evidence. In order to remedy this, we will conduct a scoping review to answer the question: what are the factors associated with gender incongruence and what level of evidence is there for each factor in the scientific literature?
We will conduct a scoping review according to the methodology specified in the JBI Manual for Evidence Synthesis (Chapter 11) and the PRISMA extension for scoping reviews (PRISMA-ScR). Four databases will be reviewed to identify papers that match our search criteria, followed by a screening of titles and abstracts, the complete reading of those articles that have not been excluded, and the coding of these using the data extraction instrument developed for this research (see S1 Appendix). Data extracted will be analyzed in terms of frequency counts of factors, types of factors and levels of evidence for each factor. Results will be presented in tabular or diagrammatic forms supported by a narrative summary.
The present review will help to map the factors associated with incongruence between biological sex and gender identity, specifying their levels of evidence. This evidence-based knowledge will be useful for clinicians evaluating gender incongruence, especially given that international guidelines recommend careful assessment of factors that may interfere with the clarity of gender identity development and decision making.
性别不一致是指生物性别与性别认同之间的不和谐。尽管有可能找到关于性别不一致病因的文献综述，但几乎所有这些都对应于非系统性的叙述性综述，因此它们没有明确说明在收集和分析来源时使用的方法，更不用说其证据水平了。为了弥补这一不足，我们将进行范围综述，以回答以下问题：与性别不一致相关的因素有哪些，以及科学文献中每个因素的证据水平如何？
我们将根据 JBI 证据综合手册（第 11 章）和扩展的 PRISMA 范围综述方法（PRISMA-ScR）进行范围综述。将对四个数据库进行审查，以确定符合我们搜索标准的论文，然后对标题和摘要进行筛选，对未被排除的文章进行完整阅读，并使用为此研究开发的数据提取工具对这些文章进行编码（见 S1 附录）。提取的数据将根据每个因素的因素频数计数、因素类型和证据水平进行分析。结果将以表格或图表形式呈现，并辅以叙述性总结。
本综述将有助于绘制与生物性别和性别认同不一致相关的因素图，并确定其证据水平。这种基于证据的知识对于评估性别不一致的临床医生将非常有用，特别是考虑到国际指南建议仔细评估可能干扰性别认同发展和决策清晰度的因素。
