不同能量密度的超脉冲二氧化碳分数激光预防眶周撕裂伤瘢痕：一项双盲、瘢痕对照研究

Ultrapulse Fractional CO 2 Laser With Different Fluences and Densities in the Prevention of Periorbital Laceration Scars: A Split-Scar, Evaluator-Blinded Study.

作者信息

Wang Jue, Wu Jiang, Chen Baoguo, Gao Quanwen

机构信息

Department of Medical Cosmetology, BeiJingJiShuiTan Hospital.

Department of Burn and Plastic Surgery, Fourth Medical Center of PLA General Hospital, Beijing, China.

出版信息

J Craniofac Surg. 2023;34(5):1536-1539. doi: 10.1097/SCS.0000000000009244. Epub 2023 Mar 13.

DOI:10.1097/SCS.0000000000009244

PMID:36913549

Abstract

BACKGROUND

Periorbital laceration can result in complex, permanent scars, and even lead to serious complications such as cicatricial ectropion. Early intervention with laser devices has been suggested as a novel modality to reduce scar formation. However, no consensus exists regarding the optimal treatment parameters for scar management. This study evaluated the efficacy and safety of ultrapulse fractional CO 2 laser (UFCL) with different fluences and densities in preventing periorbital surgical scars.

OBJECTIVE

To assess the efficacy and safety of UFCL with different fluences and densities in the prevention of periorbital laceration scars.

METHODS

A prospective, randomized, blinded study was conducted on 90 patients with periorbital laceration scars of 2 weeks old. Four treatment sessions of UFCL were administered to each half of the scar at 4-week intervals, with halves treated with high fluences with low density versus low fluences with low-density treatment. Vancouver Scar Scale was used to assess the 2 portions of each individual scar at baseline, final treatment, and 6 months. The patient's 4-point satisfaction scale was used to evaluate the patient's satisfaction at baseline and 6 months. Safety was evaluated by registration of adverse events.

RESULTS

Eighty-two of 90 patients completed the clinical trial and follow-up. There was no significant difference in Vancouver Scar Scale and satisfaction score between different laser settings between the two groups ( P > 0.05). Adverse events were minor and no long-term side effects were noted.

CONCLUSIONS

Early application of UFCL is a safe, strategy to significantly improve the final traumatic periorbital scar appearance. Objective evaluation of scars did not identify differences in scar appearance between high fluences with low density versus low fluences with low density of UFCL treatment.

LEVEL OF EVIDENCE

Level III.

摘要

背景

眶周裂伤可导致复杂的永久性瘢痕，甚至引发严重并发症，如瘢痕性睑外翻。有人提出早期使用激光设备作为减少瘢痕形成的一种新方法。然而，关于瘢痕管理的最佳治疗参数尚无共识。本研究评估了不同能量密度的超脉冲分数二氧化碳激光（UFCL）预防眶周手术瘢痕的疗效和安全性。

目的

评估不同能量密度的UFCL预防眶周裂伤瘢痕的疗效和安全性。

方法

对90例眶周裂伤后2周瘢痕患者进行前瞻性、随机、双盲研究。对瘢痕的每一半每隔4周进行4次UFCL治疗，一半采用高能量低密度治疗，另一半采用低能量低密度治疗。在基线、最终治疗和6个月时，使用温哥华瘢痕量表评估每个患者瘢痕的两部分。使用患者4分满意度量表评估患者在基线和6个月时的满意度。通过记录不良事件评估安全性。