Neuroscience Center, University of North Carolina, Chapel Hill, NC 27599, USA.
Neuroscience Center, University of North Carolina, Chapel Hill, NC 27599, USA; Department of Cell Biology and Physiology, University of North Carolina, Chapel Hill, NC 27599, USA.
Curr Opin Neurobiol. 2023 Jun;80:102704. doi: 10.1016/j.conb.2023.102704. Epub 2023 Mar 11.
Bidirectional communication between astrocytes and neurons is essential for proper brain development. Astrocytes, a major glial cell type, are morphologically complex cells that directly interact with neuronal synapses to regulate synapse formation, maturation, and function. Astrocyte-secreted factors bind neuronal receptors to induce synaptogenesis with regional and circuit-level precision. Cell adhesion molecules mediate the direct contact between astrocytes and neurons, which is required for both synaptogenesis and astrocyte morphogenesis. Neuron-derived signals also shape astrocyte development, function, and molecular identity. This review highlights recent findings on the topic of astrocyte-synapse interactions, and discusses the importance of these interactions for synapse and astrocyte development.
星形胶质细胞和神经元之间的双向通讯对于大脑的正常发育至关重要。星形胶质细胞是一种主要的神经胶质细胞，其形态复杂，可直接与神经元突触相互作用，以调节突触的形成、成熟和功能。星形胶质细胞分泌的因子与神经元受体结合，以诱导具有区域和回路水平精确性的突触形成。细胞黏附分子介导星形胶质细胞和神经元之间的直接接触，这对于突触形成和星形胶质细胞形态发生都是必需的。神经元衍生的信号也塑造了星形胶质细胞的发育、功能和分子特征。这篇综述强调了星形胶质细胞-突触相互作用的最新研究发现，并讨论了这些相互作用对于突触和星形胶质细胞发育的重要性。
