Molecular Parasitology Group (GEPAMOL, for the term in Spanish), Biomedical Research Center, Faculty of Health Sciences, Universidad del Quindío, Armenia, Colombia.
Faculty of Agroindustry, University of Quindio, Armenia, Colombia.
Psychiatry Res. 2023 May;323:115130. doi: 10.1016/j.psychres.2023.115130. Epub 2023 Mar 8.
Strong evidence exists based on metanalysis of the relationship between toxoplasmosis and many psychiatric diseases: schizophrenia, bipolar disorder, and suicidal behavior. Herein, we estimate the number of cases based on the attributable fraction due to toxoplasmosis on these diseases. The population attributable fraction of mental disease associated with toxoplasmosis was 20,4% for schizophrenia; 27,3% for bipolar disorder; and 0,29% for suicidal behavior (self-harm). The lower and upper estimated number of people with mental disease associated with toxoplasmosis was 4'816.491 and 5'564.407 for schizophrenia; 6'348.946 and 7'510.118,82 for bipolar disorder; and 24.310 and 28.151 for self-harm; for a global total lower estimated number of 11'189.748 and global total upper estimated number of 13'102.678 people with mental disease associated with toxoplasmosis for the year 2019. According to the prediction through the Bayesian model of risk factors for toxoplasmosis associated with mental disease, these varied in importance geographically; thus, in Africa, the most important risk factor was water contamination and in the European region, the cooking conditions of meats. Toxoplasmosis and mental health should be a research priority given the enormous potential impact of reducing this parasite in the general population.
大量证据表明，弓形体病与许多精神疾病之间存在关联，如精神分裂症、双相情感障碍和自杀行为。在此，我们根据弓形体病对这些疾病的归因分数来估计病例数。精神疾病与弓形体病相关的人群归因分数为：精神分裂症为 20.4%；双相情感障碍为 27.3%；自杀行为（自残）为 0.29%。与弓形体病相关的精神疾病患者的估计人数下限和上限分别为：精神分裂症为 4816491 人和 5564407 人；双相情感障碍为 6348946 人和 751011882 人；自残为 24310 人和 28151 人；全球与弓形体病相关的精神疾病患者总人数估计下限为 11189748 人，上限为 13102678 人。根据与精神疾病相关的弓形体病风险因素的贝叶斯模型预测，这些因素在地理上的重要性各不相同；因此，在非洲，最重要的风险因素是水污染，而在欧洲地区，肉类的烹饪条件则是重要因素。鉴于减少人群中这种寄生虫的巨大潜在影响，弓形体病和精神健康应该成为研究重点。
