Department of Pharmacology and Department of Advanced Translational Medicine, School of Medicine, Konkuk University, 120 Neungdong-ro, Gwangjin-gu, Seoul 05029, Republic of Korea.
Department of Pharmacology and Department of Advanced Translational Medicine, School of Medicine, Konkuk University, 120 Neungdong-ro, Gwangjin-gu, Seoul 05029, Republic of Korea; Department of Integrative Biotechnology, College of Science and Technology, Sahmyook University, Seoul 01795, Republic of Korea.
Biomed Pharmacother. 2023 May;161:114511. doi: 10.1016/j.biopha.2023.114511. Epub 2023 Mar 11.
Alzheimer's disease (AD) is a well-known neurodegenerative brain disease, and no curative treatment has yet been developed. The main symptoms include various brain lesions, caused by amyloid β (Aβ) aggregation, and cognitive decline. Therefore, it is believed that substances that control Aβ will inhibit the onset of Alzheimer's disease and slow its progression. In this study, the effect of phyllodulcin, a major component of hydrangea, on Aβ aggregation and brain pathology in an animal model of AD was studied. Phyllodulcin inhibited the aggregation of Aβ and decomposed the pre-aggregated Aβ in a concentration-dependent manner. In addition, it inhibited the cytotoxicity of Aβ aggregates. Oral administration of phyllodulcin improved Aβ-induced memory impairments in normal mice, reduced Aβ deposition in the hippocampus, inhibited the activation of microglia and astrocytes, and improved synaptic plasticity in 5XFAD mice. These results suggest that phyllodulcin may be a candidate for the treatment of AD.
阿尔茨海默病（AD）是一种众所周知的神经退行性脑疾病，目前尚无有效的治疗方法。其主要症状包括各种脑损伤，由淀粉样蛋白β（Aβ）聚集引起，并伴有认知能力下降。因此，人们认为控制 Aβ的物质将抑制阿尔茨海默病的发病并减缓其进展。在这项研究中，研究了绣球花的主要成分之一 phyllodulcin 对 AD 动物模型中 Aβ聚集和脑病理学的影响。 Phyllodulcin 以浓度依赖性方式抑制 Aβ聚集并分解预聚集的 Aβ。此外，它还抑制了 Aβ聚集体的细胞毒性。 Phyllodulcin 的口服给药改善了正常小鼠的 Aβ诱导的记忆障碍，减少了海马体中的 Aβ沉积，抑制了小胶质细胞和星形胶质细胞的激活，并改善了 5XFAD 小鼠的突触可塑性。这些结果表明，phyllodulcin 可能是治疗 AD 的候选药物。
