Jin Tian, Zhang Yong, Botchway Benson O A, Huang Min, Lu Qicheng, Liu Xuehong
Department of Histology and Embryology, Medical College, Shaoxing University, Zhejiang, China.
Institute of Neuroscience, Zhejiang University School of Medicine, Hangzhou, China; Bupa Cromwell Hospital, London, UK.
Biomed Pharmacother. 2023 May;161:114515. doi: 10.1016/j.biopha.2023.114515. Epub 2023 Mar 11.
Amyotrophic lateral sclerosis (ALS) is a chronic neurodegenerative disease with poor prognosis. The intricacies surrounding its pathophysiology could partly account for the lack of effective treatment for ALS. Sestrin2 has been reported to improve metabolic, cardiovascular and neurodegenerative diseases, and is involved in the direct and indirect activation of the adenosine 5'-monophosphate (AMP)-activated protein kinase (AMPK)/silent information regulator 1 (SIRT1) axis. Quercetin, as a phytochemical, has considerable biological activities, such as anti-oxidation, anti-inflammation, anti-tumorigenicity, and neuroprotection. Interestingly, quercetin can activate the AMPK/SIRT1 signaling pathway to reduce endoplasmic reticulum stress, and alleviate apoptosis and inflammation. This report examines the molecular relationship between Sestrin2 and AMPK/SIRT1 axis, as well as the main biological functions and research progress of quercetin, together with the correlation between quercetin and Sestrin2/AMPK/SIRT1 axis in neurodegenerative diseases.
肌萎缩侧索硬化症（ALS）是一种预后较差的慢性神经退行性疾病。围绕其病理生理学的复杂性可能部分解释了ALS缺乏有效治疗方法的原因。据报道，Sestrin2可改善代谢、心血管和神经退行性疾病，并参与5'-单磷酸腺苷（AMP）激活的蛋白激酶（AMPK）/沉默信息调节因子1（SIRT1）轴的直接和间接激活。槲皮素作为一种植物化学物质，具有相当多的生物活性，如抗氧化、抗炎、抗肿瘤和神经保护作用。有趣的是，槲皮素可以激活AMPK/SIRT1信号通路以减轻内质网应激，并减轻细胞凋亡和炎症。本报告研究了Sestrin2与AMPK/SIRT1轴之间的分子关系，以及槲皮素的主要生物学功能和研究进展，以及槲皮素与神经退行性疾病中Sestrin2/AMPK/SIRT1轴之间的相关性。
