Barton Jason Js, Stubbs Jacob L, Paquette Sebastien, Duchaine Brad, Schlaug Gottfried, Corrow Sherryse L
Human Vision and Eye Movement Laboratory, Departments of Medicine (Neurology), Ophthalmology and Visual Science, University of British Columbia, Vancouver, Canada.
Music and Neuroimaging Laboratory, Department of Neurology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA, USA.
Neuropsychologia. 2023 May 3;183:108540. doi: 10.1016/j.neuropsychologia.2023.108540. Epub 2023 Mar 11.
Acquired prosopagnosia is often associated with other deficits such as dyschromatopsia and topographagnosia, from damage to adjacent perceptual networks. A recent study showed that some subjects with developmental prosopagnosia also have congenital amusia, but problems with music perception have not been described with the acquired variant.
Our goal was to determine if music perception was also impaired in subjects with acquired prosopagnosia, and if so, its anatomic correlate.
We studied eight subjects with acquired prosopagnosia, all of whom had extensive neuropsychological and neuroimaging testing. They performed a battery of tests evaluating pitch and rhythm processing, including the Montréal Battery for the Evaluation of Amusia.
At the group level, subjects with anterior temporal lesions were impaired in pitch perception relative to the control group, but not those with occipitotemporal lesions. Three of eight subjects with acquired prosopagnosia had impaired musical pitch perception while rhythm perception was spared. Two of the three also showed reduced musical memory. These three reported alterations in their emotional experience of music: one reported music anhedonia and aversion, while the remaining two had changes consistent with musicophilia. The lesions of these three subjects affected the right or bilateral temporal poles as well as the right amygdala and insula. None of the three prosopagnosic subjects with lesions limited to the inferior occipitotemporal cortex exhibited impaired pitch perception or musical memory, or reported changes in music appreciation.
Together with the results of our previous studies of voice recognition, these findings indicate an anterior ventral syndrome that can include the amnestic variant of prosopagnosia, phonagnosia, and various alterations in music perception, including acquired amusia, reduced musical memory, and subjective reports of altered emotional experience of music.
后天性面孔失认症常与其他缺陷相关，如色盲和地形定向障碍，这是由于相邻感知网络受损所致。最近一项研究表明，一些患有发育性面孔失认症的受试者也患有先天性失乐感，但后天性面孔失认症患者的音乐感知问题尚未见报道。
我们的目标是确定后天性面孔失认症患者的音乐感知是否也受损，若受损，其解剖学关联因素是什么。
我们研究了8名后天性面孔失认症患者，他们均接受了广泛的神经心理学和神经影像学测试。他们进行了一系列评估音高和节奏处理的测试，包括蒙特利尔失乐感评估量表。
在组水平上，相对于对照组，颞叶前部病变的受试者在音高感知方面受损，但枕颞叶病变的受试者未出现这种情况。8名后天性面孔失认症患者中有3名音高感知受损，而节奏感知未受影响。这3名患者中有2名还表现出音乐记忆减退。这3名患者均报告了他们对音乐的情感体验发生了变化：1名报告有音乐快感缺失和厌恶感，而另外2名患者的变化符合音乐ophilia。这3名患者的病变影响了右侧或双侧颞极以及右侧杏仁核和脑岛。3名病变仅限于枕颞叶下部皮质的面孔失认症患者均未表现出音高感知或音乐记忆受损，也未报告音乐欣赏方面的变化。
结合我们之前关于语音识别研究的结果，这些发现表明存在一种前腹侧综合征，可能包括面孔失认症的遗忘型、声音失认症以及音乐感知的各种改变，包括后天性失乐感、音乐记忆减退以及音乐情感体验改变的主观报告。
