Sedakova L A, Bukharova I K, Treshchalin I D, Syrkin A B
Eksp Onkol. 1987;9(5):76-7.
An indole alkaloid isolated from Catharanthus roseus in the Soviet Union and named amotin differs in terpenoid moiety structure of the indole part of the molecule from the foreign preparation vinblastine and its Soviet analog rosevine. In experimental study amotin has exhibited a high antileukemic activity which was more expressed than that of vinblastine. Tolerant doses of amotin cause moderate reversible morphological alterations in hematopoietic organs, gastrointestinal mucosa, liver, kidney, adrenals, testes, ovaries.
苏联从长春花中分离出一种吲哚生物碱，命名为阿莫廷，其分子吲哚部分的萜类部分结构与国外制剂长春碱及其苏联类似物玫瑰树碱不同。在实验研究中，阿莫廷表现出很高的抗白血病活性，比长春碱的活性更强。阿莫廷的耐受剂量会导致造血器官、胃肠道黏膜、肝脏、肾脏、肾上腺、睾丸、卵巢出现中度可逆的形态学改变。
