DDX47 仅与某些其他解旋酶一起解开 R 环。

DDX47 untangles R-loops with only certain other helicases.

机构信息

Segal Cancer Center, Lady Davis Institute for Medical Research, McGill University, Montréal, Québec H3T 1E2, Canada; Gerald Bronfman Department of Oncology McGill University, Montréal, Québec H3T 1E2, Canada; Department of Biochemistry, McGill University, Montréal, Québec H3T 1E2, Canada; Department of Human Genetics McGill University, Montréal, Québec H3T 1E2, Canada; Department of Medicine, McGill University, Montréal, Québec H3T 1E2, Canada.

出版信息

Trends Cell Biol. 2023 May;33(5):359-360. doi: 10.1016/j.tcb.2023.03.001. Epub 2023 Mar 11.

DOI:10.1016/j.tcb.2023.03.001

PMID:36914533

Abstract

R-loops, formed transiently during gene transcription, are tightly controlled to avoid conflict with ongoing processes. Marchena-Cruz et al. identified DExD/H box RNA helicase DDX47 using a new R-loop resolving screen and defined a unique role for this helicase in nucleolar R-loops and its interplay with senataxin (SETX) and DDX39B.

摘要

R 环在基因转录过程中短暂形成，其形成受到严格控制，以避免与正在进行的过程发生冲突。Marchena-Cruz 等人利用一种新的 R 环解析筛选方法，发现了 DExD/H 盒 RNA 解旋酶 DDX47，并定义了该解旋酶在核仁 R 环及其与 SETX 和 DDX39B 相互作用中的独特作用。